CoCA — Aktiivsus-tähelepanuhäirega koosesinevad haigused ja tervisehäired / Comorbid Conditions of Attention Deficit/Hyperactive Disorders
CoCA kodulehekülg.Psychiatric disorders are highly co-morbid, both with somatic and other mental disorders, and are one of the last areas of medicine where disease classifications are driven by phenomenology rather than pathophysiology. Here, we will study the comorbidity between the most frequent psychiatric conditions, attention-deficit/hyperactivity disorder (ADHD), mood and anxiety disorders, substance use disorders (SUD), and a highly prevalent somatic disorder, i.e. obesity. In this project, the CoCA consortium will:
• specify the population prevalence and sex-specificity of comorbidity of ADHD’s comorbidity with mood and anxiety disorders, SUD, and obesity across the lifespan (WP1) • determine the socioeconomic impact of ADHD in conjunction with its common comorbid disorders (WP1)
• specify the genetic and environmental contributions to the overlap among the disorders (WP2) • determine the biological mechanisms underlying ADHD and its comorbid disorders (mood and anxiety disorders, SUD, obesity) (WP2,3,4):
o Sleep and the circadian rhythm system (CIRCA system) (WP2,3) o Reward processing system and dopaminergic neurotransmission therein (DA system) (WP2,4)
o Additional, currently unknown biological pathways derived from genetic big data studies (WP2) • test biomarkers from candidate systems (CIRCA, DA) and identify novel ones (WP2,3,4)
• develop algorithms to predict the development of ADHD’s comorbidities based on epidemiological/genetic data as well as the CIRCA/DA systems (WP7) • improve the diagnosis of ADHD-related comorbidity in adolescence / early adulthood through mobile healthcare (mHealth) approaches (WP5)
• develop an mHealth approach to support patients in daily life (mHealth-based monitoring and coaching) (WP5,6) • establish effect sizes of non-pharmacologic treatments for ADHD with comorbid obesity and depression by targeting the CIRCA/DA systems with chronobiological approaches, physical exercise and mHealth-based coaching (WP6)
• explore targets for novel pharmacologic treatment strategies for ADHD and its comorbid disorders (WP8) • disseminate results to the public, emphasizing the role of life-style modifications for prevention (WP9)
• educate and train a new generation of inter- and transdisciplinary researchers and clinicians (WP10)
(2019)Objective: Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low ...
Association of the COMT Val108/158Met genotype with professional career and education: The Val-allele is more frequent in managers and in enterprising occupations (ScienceDirect, 2018-01)Catechol-O-methyl transferase (COMT) is a key player in neurotransmission by catecholamines, and the functional COMT Val108/158Met polymorphism is strongly related to prefrontal reactivity and to dopamine levels. As dopamine ...
(ScienceDirect, 2019-09)Orexins, alternatively called hypocretins, are neuropeptides with crucial role in maintaining wakefulness. The orexin system is thought to mediate a coordinated defense response but thus far investigated from the flight, ...
Efficacy of intervention at traffic schools reducing impulsive action, and association with candidate gene variants (Acta Neuropsychiatrica, 2019)OBJECTIVE: Road traffic injuries are the leading cause of death among young people. Recognition of the contribution of impulsive behaviour may help novice drivers to behave more safely. Previously a brief intervention ...
Relapse of drunk driving and association with traffic accidents, alcohol-related problems, and biomarkers of impulsivity (Cambridge University Press, 2018)Objective: Individual biological predispositions should play a role in risky driving behaviour. Platelet monoamine oxidase (MAO) activity, dopamine transporter gene (DAT1) and neuropeptide S receptor 1 (NPSR1) gene ...
Association between Transcription Factor AP-2B genotype, obesity, insulin resistance and dietary intake in a longitudinal birth cohort study Transcription Factor AP-2B associated with obesity (Springer Nature, 2019)The development of obesity has a large genetic component, and the gene encoding the transcription factor 2 beta (TFAP2B) has been identified as one of the responsible factors. We investigated the effect of TFAP2B intron 2 ...