Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length

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dc.contributor"European Union (EU)" and "Horizon 2020"
dc.contributor.authorLaisk, Triin
dc.contributor.authorKukuškina, Viktorija
dc.contributor.authorPalmer, Duncan
dc.contributor.authorLaber, Samantha
dc.contributor.authorChen, Chia-Yen
dc.contributor.authorFerreira, Teresa
dc.contributor.authorRahmioglu, Nilufer
dc.contributor.authorZondervan, Krina
dc.contributor.authorBecker, Christian
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorLippincott, Margaret
dc.contributor.authorSalumets, Andres
dc.contributor.authorGranne, Ingrid
dc.contributor.authorSeminara, Stephanie
dc.contributor.authorNeale, Benjamin
dc.contributor.authorMägi, Reedik
dc.contributor.authorLindgren, Cecilia M
dc.date.accessioned2019-02-27T10:05:52Z
dc.date.available2019-02-27T10:05:52Z
dc.date.issued2018
dc.description.abstractThe normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.et
dc.identifier.urihttps://doi.org/10.1093/hmg/ddy317
dc.identifier.urihttp://hdl.handle.net/10062/63436
dc.language.isoenget
dc.publisherHuman Molecular Geneticset
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/692065///WIDENLIFEet
dc.relation.ispartofseriesHuman Molecular Genetics;Volume 27, Issue 24
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectgene expression regulationet
dc.subjectgeneset
dc.subjectmenstrual cycleet
dc.subjecthypothalamic-pituitary-gonadal axiset
dc.subjectgenome-wide association studyet
dc.titleLarge-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle lengthet
dc.typeinfo:eu-repo/semantics/articleet

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