Kasutatud kirjandus ja lisalugemine

iDevice ikoon Ülevaateartiklid
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  • Regan L: A prospective study on early abortion. In Beard RW, Sharp F [eds]: Early Pregnancy Loss: Mechanisms and Treatment, p 22. London, Royal College of Obstetricians and Gynaecologists, 1988.
  • RCOG. Royal College of Obstetricians and Gynecologists (RCOG)
    Guideline 17: The Investigation and treatment of couples of recurrent miscarriage. RCOG Prees, London 2003.
  • Toth B, Jeschke U, Rogenhofer N, Scholz C, Würfel W, Thaler CJ, Makrigiannakis A.Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol. 2010;85(1):25-32.
  • Tuckerman E, Laird SM, Stewart R, Wells M, Li TC. Markers of endometrial function in women with unexplained recurrent pregnancy loss: a comparison between morphologically normal and retarded endometrium. Hum Reprod 2004;19(1):196-205
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iDevice ikoon Eluviiside ja keskkonna tegurid
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    Plasma folate levels and risk of spontaneous abortion. JAMA. 2002;288(15):1867-73.
  • George L, Granath F, Johansson AL, Olander B, Cnattingius S. Risks of repeated miscarriage.
    Risks of repeated miscarriage. Paediatr Perinat Epidemiol. 2006;20(2):119-26.
  • March of Dimes. Caffeine in pregnancy 2008. Available at: http://www.marchofdimes.com/professionals
  • McGregor DG.Occupational exposure to trace concentrations of waste anesthetic gases. Mayo Clin Proc. 2000;75(3):273-7
  • Nelen WL Blom HJ, Steegersm EA, den Heijer M, Eskes TK.Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis. Fertil Steril 2000; 74:1196-1199
  • Pollack AZ, Buck Louis GM, Sundaram R, Lum KJ. Caffeine consumption and miscarriage: a prospective cohort study. Fertil Steril. 2010 Jan;93(1):304-6.
  • Ren A, Wang J . Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis. Fertil Steril 2006; 86: 1716-1722
  • Rumbold A, Middleton P, Crowther CA. Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev 2005(2):CD004073.
  • Weng X, Odouli R, and Li D-K. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 2008;198:279.e1-279.e8.

iDevice ikoon Sugutrakti põletikud ja rasedustüsistused
  • Baud, D., L. Regan, G. Greub. 2008. Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes. Curr. Opin. Infect. Dis. 21: 70-76
  • Collodel G, Giannerini V, Antonio Pascarelli N, Federico MG, Comodo F, Moretti E. TEM and FISH studies in sperm from men of couples with recurrent pregnancy loss. Andrologia.
    2009;41(6):352-60.
  • Equils O, Lu D, Gatter M, Witkin SS, Bertolotto C, Arditi M, McGregor JA, Simmons CF, Hobel CJ.Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4. J Immunol. 2006 Jul 15;177(2):1257-63.
  • Everaert K, Mahmou A, Depuyd C, Maeyaer M, Comhaire F. Chronic prostatitis and male accessory gland infection - is there an impact on male infertility (diagnosis and therapy)? Andrologia 2003;35(5):325-330.
  • Nunez-Calonge R, Caballero P, Redondo C, Baquero F, Martinez-Ferrer M, Meseguer MA. Ureaplasma urealyticum reduces motility and induces membrane alterations in human spermatozoa. Hum Reprod 1998;13(1O):2756-61
  • Oakeshott P, Hay P, Hay S, Steinke F, Rink E, Kerry S. Association between bacterial vaginosis or chlamydial infection and miscarriage before 16 weeks' gestation: prospective community based cohort study. BMJ 2002;7;325(7376):1334.
  • Puscheck EE, Jeyendran RS. The impact of male factor on recurrent pregnancy loss. Curr Opin Obstet Gynecol. 2007; 19(3):222-8.
  • Ralph SG, Rutherford AJ, Wilson JD. Influence of bacterial vaginosis on conception and miscarriage in the first trimester: cohort study. BMJ 1999;319(7204):220-223.
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  • Saxena P, Misro MM, Roy S, Chopra K, Sinha D, Nandan D, Trivedi SS. Possible role of male factors in recurrent pregnancy loss. Indian J Physiol Pharmacol. 2008;52(3):274-82.
  • Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril 1996;66(1):24-9. 

iDevice ikoon Emaka anatoomilised eripärad ja rasedustüsistused
  • Bajekal N, Li TC. Fibroids, infertility and pregnancy wastage. Hum Reprod Update 2000;6(6):614–620.
  • Campo S, Campo V, Gambadauro P. Reproductive outcome before and after laparo-scopic or abdominal myomectomy for subserous or intramural myomas. Eur J Obstet Gynecol Reprod Biol 2003;110(2):215–219.
  • Devi Wold AS, Pham N, Arici A. Anatomic factors in recurrent pregnancy loss. Semin Reprod Med 2006;24(1):25–32.
  • Emaka väärasetused ja rasedustüsistused: http://emedicine.medscape.com/article/272497-print
  • Garcia-Enguidanos A, Calle ME, Valero J, Luna S, Dominguez-Rojas V. Risk factors in miscarriage: a review. Eur J Obstet Gynecol Reprod Biol 2002;102(2):111–119.
  • Li TC, Mortimer R, Cooke ID. Myomectomy: a retrospective study to examine reproductive performance before and after surgery. Hum Reprod 1999;14(7):1735–1740.
  • Propst AM, Hill JA, 3rd. Anatomic factors associated with recurrent pregnancy loss. Semin Reprod Med 2000;18(4):341–350.
  • Saravelos SH, Cocksedge KA, Li TC. Prevalence and diagnosis of congenital uterine anomalies in women with reproductive failure: a critical appraisal. Hum Reprod Update 2008;14(5):415-29.

iDevice ikoon Kromosoomianomaaliad ja raseduse katkemine
  • Angell RR, Sandison A, Bain AD. Chromosome variation in perinatal mortality: a survey of 500 cases.J Med Genet. 1984; 21(1):39-44.
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  • Franssen MT, Korevaar JC, Leschot NJ, Bossuyt PM, Knegt AC, Gerssen-Schoorl KB, et al. Selective chromosome analysis in couples with two or more miscarriages: case-control study. BMJ 2005;331(7509):137-41.
  • Carp H, Toder V, Aviram A, Daniely M, Mashiach S, Barkai G. Karyotype of the abortus in recurrent miscarriage. Fertil Steril 2001; 75(4): 678-82.
  • Gardner R S, GR. Chromosome abnormalities and genetic counseling. 2nd ed. New York: Oxford University Press, 1996. pp. 59,190, 248,313-317.
  • Hertig AT, Rock J: On the development of the early human ovum, with special reference to the trophoblast of the previllous stage: A description of seven normal and 5 pathological human ova. Am J Obstet Gynecol 47: 149, 1944
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  • Hertig AT, Rock J, Adams EC. Description of human ova within the first 17 days of development. Am J Anat 98: 435, 1956
  • Macklon NS, Geraedts JP, Fauser BC. Conception to ongoing pregnancy: the 'black box' of early pregnancy loss. Hum Reprod Update 2002 8(4):333-43.
  • Ogasawara M, Aoki K, Okada S, Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 2000;73(2):300-4.
  • Philipp T, Philipp K, Reiner A, Beer F, Kalousek DK. Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies. Hum Reprod 2003;18(8):1724-32.
  • Quenby S, Vince G, Farquharson R, Aplin J. Recurrent miscarriage: a defect in nature's quality control? Hum Reprod. 2002;17(8):1959-63.
  • RCOG. Royal College of Obstetricians and Gynecologists (RCOG) Guideline 17: The Investigation and treatment of couples of recurrent miscarriage. RCOG Press, London 2003 http://www.rcog.org.uk/womens-health/clinical-guidance/investigation-and-treatment-couples-recurrent-miscarriage-green-top-
  • Rubio C, Simón C, Vidal F, Rodrigo L, Pehlivan T, Remohí J, Pellicer A. Chromosomal abnormalities and embryo development in recurrent miscarriage couples. Hum Reprod. 2003; 18(1):182-8.
  • Simpson J, Carson S.Genetic abnd nongenetic causes of pregnancy loss. Glob. libr. women's med., ISSN: 1756-2228) 2008; DOI 10.3843/GLOWM.10319. http://www.glowm.com/index.html?p=glowm.cml/section_view&articleid=318
  • Stephenson MD, Sierra S. Reproductive outcomes in recurrent pregnancy loss associated with a parental carrier of a structural chromosome rearrangement. Hum Reprod. 2006;21(4):1076-82
  • Stephenson MD, Awartani KA, Robinson WP. Cytogenetic analysis of miscarriages from couples with recurrent miscarriage: a case-control study. Hum Reprod 2002;17(2):446-51.
  • Strachan T, Read AP Human Molecular Genetics, 2nd edition, Online book (http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hmg)
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  • Vanneste E, Voet T, Le Caignec C, Ampe M, Konings P, Melotte C, Debrock S, Amyere M, Vikkula M, Schuit F, Fryns JP, Verbeke G, D'Hooghe T, Moreau Y, Vermeesch JR. Chromosome instability is common in human cleavage-stage embryos. Nat Med. 2009;15(5):577-83.
  • Warburton D, Kline J, Stein Z, Hutzler M, Chin A, Hassold T.Does the karyotype of a spontaneous abortion predict the karyotype of a subsequent abortion? Evidence from 273 women with two karyotyped spontaneous abortions. Am J Hum Genet. 1987; 41(3):465-83.

iDevice ikoon Autoantikehade ja kilpnäärme hormoonide seos raseduse katkemisega.
  • Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ, Stagnaro-Green A. Management of thyroid dysfunction during pregnancy and postpartum:an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2007;92(8 Suppl):S1-47.
  • De Vivo A, Mancuso A, Giacobbe A, Moleti M, Maggio Savasta L, De Dominici R, Priolo AM, Vermiglio F. Thyroid function in women found to have early pregnancy loss. Thyroid. 2010;20(6):633-7.
  • Haller K.Doktoritöö: Antibodies to follicle stimulating hormone : significance in female infertility. 2007
    Dissertationes medicinae Universitatis Tartuensis, 1024-395X; 135 URL: http://hdl.handle.net/10062/2486
  • Poppe K, Glinoer D. Thyroid autoimmunity and hypothyroidism before and during pregnancy. Hum Reprod Update. 2003 Mar-Apr;9(2):149-61.
  • Soni S, Badawy SZ. Celiac disease and its effect on human reproduction: a review. J Reprod Med. 2010;55(1-2):3-8.

iDevice ikoon Trombofiilsed seisundid ja antifosfolipiidsündroom
  • Bayston T, Lane D, for the Plasma Coagulation Inhibitors Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Antithrombin mutation database. Imperial College London. http://www1.imperial.ac.uk/medicine/about/divisions/is/haemo/coag/antithrombin/.
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  • Godwin JE. Protein S deficiency 2009 http://emedicine.medscape.com/article/205582-overview
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  • Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med 2002;346(10):752-63
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  • Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306
  • Mitchell CA, Rowell JA, Hau L, Young JP, Salem HH. A fatal thrombotic disorder associated with an acquired inhibitor of protein C. N Engl J Med. 1987;317(26):1638-42
  • Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007;109(8):3161-72
  • Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Hae morrh.1965;13:516-30
  • Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996;348(9032):913-6.
  • Rajan A, Grethlein SJ. McKenna R. Antithrombin deficiency 2009. http://emedicine.medscape.com/article/198573-overview
  • Reitsma PH, Bernardi F, Doig RG, Gandrille S, on behalf of the Subcommittee on Plasma Coagulation Inhibitors of the Scientific and Standardization Committee of the ISTH. Protein C deficiency: a database of mutations, 1995 update. Thromb Haemost.1995;73(5):876-89.
  • Rey E, Garneau P, David M, Gauthier R, Leduc L, Michon N, et al. Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: a pilot randomized controlled trial. J Thromb Haemost 2009;7(1):58-64

iDevice ikoon Hormonaalsed häired ja raseduse katkemine
  • Daya S. Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials. Br J Obstet Gynaecol 1989;96(3):275-80.
  • Endometrial Database http://www.endometrialdatabase.com
  • Haas DM, Ramsey PS. Progestogen for preventing miscarriage. Cochrane Database Syst Rev 2008(2):CD003511.
  • Habara T, Nakatsuka M, Konishi H, Asagiri K, Noguchi S, Kudo T. Elevated blood flow resistance in uterine arteries of women with unexplained recurrent pregnancy loss. Hum Reprod 2002;17(1):190-4.
  • Horcajadas JA, Pellicer A, Simón C.Wide genomic analysis of human endometrial receptivity: new times, new opportunities. Hum Reprod Update 2007;13(1): 77-86.
  • Jakubowicz DJ, Iuorno MJ, Jakubowicz S, Roberts KA, Nestler JE. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 2002;87(2):524-9.
  • Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod. 2004; 19(7):1644-6.
  • Murray MJ, Meyer WR, Zaino RJ, Lessey BA, Novotny DB, Ireland K, Zeng D and Fritz MA (2004) A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril 81,1333–1343.
  • Nakatsuka M, Habara T, Noguchi S, Konishi, H, Kudo T. Impaired Uterine Arterial Blood Flow in Pregnant Women With Recurrent Pregnancy Loss J Ultrasound Med 2003;22(1):27-31.
  • Noyes RW, Hertig AT, Rock J. 1950 Dating the endometrial biopsy. Fertil Steril 1950; 1:3–17.
    Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol 1975; 122: 262–263.
  • Ponnampalam AP, Weston GC, Trajstman AC, Susil B, Rogers PA.
    Molecular classification of human endometrial cycle stages by transcriptional profiling.Mol Hum Reprod. 2004;10(12):879-93.
  • Quenby S, Farquharson R. Human Chorionic Gonadotropin supplementation in recurring pregnancy loss: a controlled trial. Fertil Steril 1994;62(4):708-710.
  • Raj R, Backos M, Rushworth F Regan L. Polycystic ovaries and recurrent miscarriage—a reappraisal Hum Reprod 2000;15(3):612-615
  • Roberts CP, Murphy AA. Endocrinopathies associated with recurrent pregnancy loss. Semin Reprod Med. 2000;18(4):357-62.
  • Scott JR, Pattison N. Human chorionic gonadotrophin for recurrent miscarriage. Cochrane Database Syst Rev 2000;(2):CD000101.
  • Quenby S, Farquharson R. Human Chorionic Gonadotropin supplementation in recurring pregnancy loss: a controlled trial. Fertil Steril 1994;62(4):708-710.
  • Steer CV, Tan SL, Mason BA, Campbell S. Midluteal-phase vaginal color Doppler assessment of uterine artery impedance in a subfertile population. Fertil Steril 1994;61(1):53-8.
  • Toth P, Lukacs H, Gimes G, Sebestyen A, Pasztor N, Paulin F, Rao CV. Clinical importance of vascular LH/hCG receptors--a review. Reprod Biol 2001;1(2):5-11.


iDevice ikoon Immunoloogilised muutused raseduse ajal
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  • El-Far M, El-Motwally Ael-G, Hashem IA, Bakry N.Biochemical role of intravaginal sildenafil citrate as a novel antiabortive agent in unexplained recurrent spontaneous miscarriage: first clinical study of four case reports from Egypt. Clin Chem Lab Med. 2009;47(11):1433-8
  • Ernst P, Bacigalupo A, Ringdén O, Ruutu T, Kolb HJ, Lawrinson S, Skacel T.A Phase 3, Randomized, Placebo-controlled Trial of Filgrastim in Patients with Haematological Malignancies Undergoing Matched-related Allogeneic Bone Marrow Transplantation. Arch Drug Inf. 2008;1(3):89-96.
  • Gaunt G, Ramin K. Immunological Tolerance of the Human Fetus. Am J Perinat 2001;18(6): 299-312.
  • Jerzak M, Kniotek M, Mrozek J, Górski A, Baranowski W. Sildenafil citrate decreased natural killer cell activity and enhanced chance of successful pregnancy in women with a history of recurrent miscarriage. Fertil Steril. 2008;90(5):1848-53.
  • Jerzak M, Niemiec T, Nowakowska A, Klochowicz M, Górski A, Baranowski W.First successful pregnancy after addition of enoxaparin to sildenafil and etanercept immunotherapy in woman with fifteen failed IVF cycles - case report. Am J Reprod Immunol. 2010;64(2):93-6.
  • Kilpatrick DC, Bevan BH, Liston WA. Association between mannan binding protein deficiency and recurrent miscarriage. Hum Reprod 1995;10(9):2501-5.
  • King K, Smith S, Chapman M, Sacks G.Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage. Hum Reprod. 2010; 25(1):52-8
  • Kruse C, Rosgaard A, Steffensen R, Varming K, Jensenius JC, Christiansen OB. Low serum level of mannan-binding lectin is a determinant for pregnancy outcome in women with recurrent spontaneous abortion. Am J Obstet Gynecol 2002;187(5):1313-20.
  • Kruse C, Steffensen R, Varming K, Christiansen OB.A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB1*03 is associated with recurrent miscarriage. Hum Reprod. 2004;19(5):1215-21.
  • Kwak-Kim JY, Chung-Bang HS, Ng SC, Ntrivalas EI, Mangubat CP, Beaman KD, Beer AE, Gilman-Sachs A. Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF. Hum Reprod 2003;18(4):767-73.
  • Makhseed M, Raghupathy R, Azizieh F, Omu A, Al-Shamali E, Ashkanani L. Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2001;16(10):2219-26.
  • Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, Weber-Carstens S, Hasper D, Keh D, Zuckermann H, Reinke P, Volk HD. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am J Respir Crit Care Med. 2009;180(7):640-8
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  • Quenby S, Kalumbi C, Bates M, Farquharson R, Vince G.Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. Fertil Steril. 2005;84(4):980-4.
  • Schust D, Andelin C. Immunology of Isolated and Recurrent Spontaneous Pregnancy Loss. Glob. libr. women's med. 2008; DOI 10.3843/GLOWM.10320
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  • Stephenson MD, Kutteh WH, Purkiss S, Librach C, Schultz P, Houlihan E, Liao C.Intravenous immunoglobulin and idiopathic secondary recurrent miscarriage: a multicentered randomized placebo-controlled trial. Hum Reprod. 2010;25(9):2203-9.
  • Scarpellini F, Sbracia M. Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial. Hum Reprod. 2009;24(11):2703-8
  • Winger EE, Reed JL. Treatment with tumor necrosis factor inhibitors and intravenous immunoglobulin improves live birth rates in women with recurrent spontaneous abortion. Am J Reprod Immunol 2008;60(1):8-16.
  • Wold AS, Arici A. Natural killer cells and reproductive failure.Curr Opin Obstet Gynecol. 2005;17(3):237-41.
  • Yang KM, Ntrivalas E, Cho HJ, Kim NY, Beaman K, Gilman-Sachs A, Kwak-Kim J. Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation. Am J Reprod Immunol. 2010;63(5):370-8.


Kristiina Rull, 2010