Browsing by Author "Pisarev, Heti"

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Demographic associations for autoantibodies in disease-free individuals of a European population
(2016) Haller-Kikkatalo, Kadri; Alnek, Kristi; Metspalu, Andres; Mihailov, Evelin; Metsküla, Kaja; Kisand, Kalle; Pisarev, Heti; Salumets, Andres; Uibo, Raivo
The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
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Erinevate meetodite võrdlus puude aastarõngaste laiuse prognoosimisel
(Tartu Ülikool, 1999) Pisarev, Heti; Fischer, K., juhendaja; Tartu Ülikool. Matemaatika-informaatikateaduskond; Tartu Ülikool. Matemaatilise statistika instituut
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HER2-positiivsete rinnakasvajate kemoteraapia kliiniline tõenduspõhisus ja kulutõhusus: tervisetehnoloogia hindamise raport TTH21
(Tartu, 2016) Adamson, Aidi; Jaal, Jana; Jõgi, Kaidi; Pisarev, Heti; Kiivet, Raul-Allan; Tartu Ülikool. Peremeditsiini ja rahvatervishoiu instituut
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Kirurgiline ravi Eestis: kuus operatsiooni arvudes
(Tartu, 2019) Kiivet, Raul-Allan; Pisarev, Heti; Ringmets, Inge; et al; Tartu Ülikool. Peremeditsiini ja rahvatervishoiu instituut
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Magnet- ja sensornavigatsioon südame rütmihäirete ravis: tervisetehnoloogia hindamise raport TTH51
(Tartu, 2020) Reile, Rainer; Pisarev, Heti; Kampus, Priit; Kiivet, Raul-Allan; Tartu Ülikool. Peremeditsiini ja rahvatervishoiu instituut
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Mammograafia rinnavähi sõeluuringus:tervisetehnoloogia hindamise raport TTH05
(2013) Võrno, Triin; Kuusemäe, Katrin; Valvere, Vahur; Padrik, Peeter; Ulp, Sulev; Pisarev, Heti; Kolde, Anastassia; Puusepp, Mai; Lippus, Hedda; Kiivet, Raul-Allan; Tartu Ülikool. Tervishoiu instituut
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Structural nested mean models in a repeated measures setting
(Tartu Ülikool, 2001) Pisarev, Heti; Fischer, Krista, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Matemaatilise statistika instituut