Browsing TransGeno - The ERA Chair for Translational Genomics and Personalized Medicine by Issue Date
Now showing items 1-14 of 14
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Cross-Sectional Study to Characterise Nicotine Dependence in Central Vietnamese Men
(SAGE, 2019)Tobacco is legally permitted for adults, easily available, and the prevalence of smoking is high. Tobacco use is the largest preventable risk factor for human disease. To reduce smoking, many countries have introduced ... -
De novo and inherited pathogenic variants in collagen-related osteogenesis imperfecta
(Wiley Periodicals, Inc., 2019)Background: Osteogenesis imperfecta (OI) is a rare genetic bone fragility disorder. In the current study, differences between the genotypes and phenotypes of de novo and inherited collagen‐related OI were investigated ... -
Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite elements
(Nature, 2019-03-13)Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several ... -
Multicomponent biomarker approach improves the accuracy of diagnostic biomarkers for psoriasis vulgaris
(2019-10-14)Accurate biomarker-based diagnosis of psoriasis vulgaris has remained a challenge; no reliable disease-specific biomarkers have yet been identified. There are several different chronic inflammatory skin diseases that can ... -
Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk
(BioMed Central Ltd, 2019-11-14)Background. Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we tested ... -
Identification of an optimal method for extracting RNA from human skin biopsy, using domestic pig as a model system.
(Nature, 2019-12-27)To evaluate skin tissue gene expression patterns correctly, extracting sufficient quantities of good quality RNA is essential. However, RNA extraction from skin tissue is challenging, as the hyaluronic acid-collagen matrix ... -
Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics
(Elsevier, 2020-01-11)Background: Wolfram syndrome (WS), caused by mutations in WFS1 gene, is a multi-targeting disease affecting multiple organ systems. Wolframin is localized in the membrane of the endoplasmic reticulum (ER), influencing Ca2+ ... -
Time-critical influences of gestational diet in a seahorse model of male pregnancy
(The Company of Biologists, 2020-02-07)Sex role reversal is not uncommon in the animal kingdom but is taken to the extreme by the Syngnathidae, in which male pregnancy is one of the most astonishing idiosyncrasies. However, critical and time-dependent environmental ... -
Individually cultured bovine embryos produce extracellular vesicles that have the potential to be used as non-invasive embryo quality markers
(2020-06)Extracellular vesicles (EVs) are membrane-bound biological nanoparticles (NPs) and have gained wide attention as potential biomarkers. We aimed to isolate and characterize EVs from media conditioned by individually cultured ... -
Paternal effects in a wild-type zebrafish implicate a role of sperm-derived small RNAs
(Wiley Online Library, 2020-06-11)While the importance of maternal effects has long been appreciated, a growing body of evidence now points to the paternal environment having an important influence on offspring phenotype. Indeed, research on rodent ... -
Zeta Potential of Extracellular Vesicles: Toward Understanding the Attributes that Determine Colloidal Stability
(ACS Publications, 2020-06-30)Extracellular vesicles (EVs), including exosomes and microvesicles (<200 nm), play a vital role in intercellular communication and carry a net negative surface charge under physiological conditions. Zeta potential (ZP) is ... -
Bovine follicular fluid and extracellular vesicles derived from follicular fluid alter the bovine oviductal epithelial cells transcriptome."
(MPDI, 2020-07-28)While follicular fluid (FF) is well known to provide an optimal environment for oogenesis, its functional roles following its release into the oviduct during ovulation are currently elusive. We hypothesized that FF and ... -
Spermatozoa induce transcriptomic alterations in bovine oviductal epithelial cells prior to initial contact
(2020-09-03)The capability of spermatozoa to directly influence maternal gene expression is already established. Indeed, some of the changes induced by spermatozoa may have a direct functional importance in the pre-conceptional period. ... -
Cellular, Extracellular and Extracellular Vesicular miRNA Profiles of Pre-Ovulatory Follicles Indicate Signaling Disturbances in Polycystic Ovaries
(MPDI, 2020-12-15)Cell-free RNAs have the potential to act as a means of gene expression regulation between cells and are therefore used as diagnostic markers describing the state of tissue environment. The origin and functions of such RNAs ...
