The role of TGFBI in wound healing and skin regeneration
Date
2021
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Abstract
The skin is an essential organ of any mammalian organism. It performs many
different functions, such as sensory, metabolic, thermoregulatory function, and others. One
of the most important functions of the skin is to create a barrier between the body and the
environment. Processes such as skin regeneration and wound healing are fundamental to
the normal functioning of the body. This research investigates the effect of Transforming
Growth Factor Beta Induced Protein (TGFBI) on skin regeneration and wound healing
through its ability to modulate cell migration and proliferation. Fibroblasts and
immortalized human keratinocytes were used during the experiments. The
immunofluorescence analysis of mouse skin tissue samples showed that TGFBI is
expressed both in healthy and healing skin, namely in the dermis. Experiments with
cultured skin cells showed that TGFBI does not affect the migration and proliferation of
keratinocytes and fibroblasts.
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Keywords
skin, wound healing, skin regeneration, extracellular matrix, TGFBI, cell migration, cell proliferation, fibroblasts, keratinocytes