Dynamics of interplanar bridges and tissue morphogenesis in Drosophila melanogaster pupal wing
Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Tartu Ülikool
Abstract
Different actin and/or tubulin-based membrane protrusions have been proposed to be one of
the means for intercellular communication needed for proper cell proliferation, cell fate
decision, and migration. Even though existence of membrane protrusions have occasionally
been described in developing tissues, their physiological roles are still poorly understood.
Microtubule-based protrusions, termed interplanar bridges, have been shown to be present in
Drosophila melanogaster pupal wing. To study the dynamics and function of these
protrusions, 5D time lapse imaging was conducted by using α-Tubulin:GFP and centrosomal
cnn:Cherry to visualize the interplanar bridges and mitotic cells. Results gathered from the
thesis show, that these structures are present during pupal wing development and appear to
play roles in regulating coordinated cell mitosis as the means of intercellular communication.
Description
Keywords
Drosophila melanogaster pupal wing, intercellular communication, microtubules, MTOCs, -TIPs