Selecting endpoints to use in preclinical trials in a mouse model of Alzheimer’s disease
Date
2021
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Tartu Ülikool
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder of the brain, that leads to cognitive
impairment. AD is characterised by the accumulation of β-amyloid peptides and tau proteins
into amyloid plaques and neurofibrillary tangles. AD currently has no cure, however promising
research and treatment is underway. The aim of this work is to determine appropriate endpoints
to use in a preclinical trial of 5xFAD mouse model of AD. In this thesis, I demonstrate endpoints
appropriate to use for preclinical trials and appropriate group and effect sizes.
Description
Keywords
Alzeimer’s disease, 5xFAD, microglia, histology