Valge, Marju, juhendajaKorhonen, Pasi Antero, juhendajaNeevits, LisbethTartu Ülikool. Matemaatika ja statistika instituutTartu Ülikool. Loodus- ja täppisteaduste valdkond2016-07-072016-07-072016http://hdl.handle.net/10062/52412The aim of this thesis is to give an overview of calculating sample size in clinical trials. First, a brief introduction to clinical trials and factors affecting sample size is given. This is followed by chapters on sample size calculations for three main trial types. Every design is then illustrated by a practical example and instructions for calculations in SAS and R software.enclinical trialsRsample sizeSASkliinilised uuringudvalimimahtbakalaureusetöödThesis