Effects of parachloroamphetamine on locomotor activity and serotonin and dopamine levels in prefrontal cortex and septum in rats with different sociability
Date
2018
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Publisher
Tartu Ülikool
Abstract
Social behaviour plays important role in many psychopathologies. Sociability has been shown to be a stable trait in animals and individual differences in sociability are related to 5-HT transmission in septum and prefrontal cortex. The aim of the current study was to investigate whether animals with different levels of sociability are differently affected by p-chloroamphetamine treatment. 5-HT, 5-HIAA and DA levels were measured in septum and PFC and locomotor activity was recorded. Although there was no difference in monoamine levels or locomotor activity between LS- and HS-animals after PCA treatment, our findings confirm previous research on the different neurodegenerative effect of PCA in different brain regions. PCA had stronger neurodegenerative effect in PFC as 5-HT and 5-HIAA levels there were lower than in septum.