Effects of parachloroamphetamine on locomotor activity and serotonin and dopamine levels in prefrontal cortex and septum in rats with different sociability
| dc.contributor.advisor | Harro, Jaanus, juhendaja | |
| dc.contributor.advisor | Kalda, Anti, juhendaja | |
| dc.contributor.author | Kastein, Gisela | |
| dc.contributor.other | Tartu Ülikool. Sotsiaalteaduste valdkond | et |
| dc.contributor.other | Tartu Ülikool. Psühholoogia instituut | et |
| dc.date.accessioned | 2018-07-19T11:41:58Z | |
| dc.date.available | 2018-07-19T11:41:58Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Social behaviour plays important role in many psychopathologies. Sociability has been shown to be a stable trait in animals and individual differences in sociability are related to 5-HT transmission in septum and prefrontal cortex. The aim of the current study was to investigate whether animals with different levels of sociability are differently affected by p-chloroamphetamine treatment. 5-HT, 5-HIAA and DA levels were measured in septum and PFC and locomotor activity was recorded. Although there was no difference in monoamine levels or locomotor activity between LS- and HS-animals after PCA treatment, our findings confirm previous research on the different neurodegenerative effect of PCA in different brain regions. PCA had stronger neurodegenerative effect in PFC as 5-HT and 5-HIAA levels there were lower than in septum. | en |
| dc.identifier.uri | http://hdl.handle.net/10062/61294 | |
| dc.language.iso | eng | et |
| dc.publisher | Tartu Ülikool | et |
| dc.rights | openAccess | et |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Estonia | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ee/ | * |
| dc.subject.other | üliõpilastööd | et |
| dc.title | Effects of parachloroamphetamine on locomotor activity and serotonin and dopamine levels in prefrontal cortex and septum in rats with different sociability | en |
| dc.title.alternative | Paraklooramfetamiini mõju psühhomotoorsele aktiivsusele ja serotoniini ja dopamiini tasemetele septumis ja prefrontaalkorteksis erineva püsisotsiaalsusega loomadel | et |
| dc.type | Thesis | en |