Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice)
| dc.contributor.author | Rajasalu, Tarvo | |
| dc.date.accessioned | 2007-10-04T07:11:39Z | |
| dc.date.available | 2007-10-04T07:11:39Z | |
| dc.date.issued | 2007-10-04T07:11:39Z | |
| dc.description.abstract | In the clinical part of the study the prevalence of genetic markers and disease-associated autoantibodies in Estonian patients with new-onset type 1 diabetes were determined, and the associations between genetic factors and autoantibodies were analysed. The experimental part of the study was carried out in RIP(rat insulin promoter)-B7.1 transgenic mice in whom the expression of the immunostimulatory B7.1 molecule in -cells increases the susceptibility of the mice to autoimmune diabetes. In the current study the main diabetogenic T cell population of this experimental model was characterised and the target epitope of the pathogenic T cell response against the insulin molecule was identified. | et |
| dc.identifier.uri | http://hdl.handle.net/10062/3991 | |
| dc.language.iso | en | et |
| dc.title | Autoimmune diabetes: an immunological study of type 1 diabetes in humans and in a model of experimental diabetes (in RIP-B7.1 mice) | et |
| dc.title.alternative | Autoimmuunne diabeet: immunoloogiline uuring 1. tüüpi diabeediga haigetel ja eksperimentaalse diabeedi mudelis (RIP-B7.1 hiirtel) | et |
| dc.type | Thesis | et |