Demographic associations for autoantibodies in disease-free individuals of a European population

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dc.contributor"European Union (EU)" and "Horizon 2020"
dc.contributor.authorHaller-Kikkatalo, Kadri
dc.contributor.authorAlnek, Kristi
dc.contributor.authorMetspalu, Andres
dc.contributor.authorMihailov, Evelin
dc.contributor.authorMetsküla, Kaja
dc.contributor.authorKisand, Kalle
dc.contributor.authorPisarev, Heti
dc.contributor.authorSalumets, Andres
dc.contributor.authorUibo, Raivo
dc.date.accessioned2019-02-26T12:52:07Z
dc.date.available2019-02-26T12:52:07Z
dc.date.issued2016
dc.description.abstractThe presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.et
dc.identifier.urihttps://doi.org/10.1038/srep44846
dc.identifier.urihttp://hdl.handle.net/10062/63411
dc.language.isoenget
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/692065///WIDENLIFEet
dc.relation.ispartofseriesScientific Reports;7, 44846
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectRisk factorset
dc.subjectMolecular medicineet
dc.titleDemographic associations for autoantibodies in disease-free individuals of a European populationet
dc.typeinfo:eu-repo/semantics/articleet

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