Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose  metabolism: a longitudinal birth cohort study

Katus, Urmeli; Villa, Inga; Ringmets, Inge; Veidebaum, Toomas; Harro, Jaanus

Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: a longitudinal birth cohort study

dc.contributor.author	Katus, Urmeli
dc.contributor.author	Villa, Inga
dc.contributor.author	Ringmets, Inge
dc.contributor.author	Veidebaum, Toomas
dc.contributor.author	Harro, Jaanus
dc.date.accessioned	2021-03-18T13:41:37Z
dc.date.available	2021-03-18T13:41:37Z
dc.date.issued	2021
dc.description.abstract	Objective: Neuropeptide Y affects several physiological functions, notably appetite regulation. We analysed the association between four single nucleotide polymorphisms (SNP) in the NPY gene (rs5574, rs16147, rs16139, rs17149106) and measures of obesity, dietary intake, physical activity, blood pressure, glucose and lipid metabolism from adolescence to young adulthood. Methods: The sample included both birth cohorts of the Estonian Children Personality Behaviour and Health Study at ages 15 (n = 1075 with available complete data), 18 (n = 913) and 25 (n = 926) years. Linear mixed-effects regression models were used for longitudinal association between NPY SNP-s and variables of interest. Associations at ages 15, 18 and 25 were analysed by ANOVA. Results: Rs5574 CC-homozygotes had a greater increase per year in waist-to-hip ratio (WHR) and a smaller decrease in daily energy intake and carbohydrate intake from age 15 to 25 years; fasting glucose and cholesterol were higher in rs5574 CC-homozygotes. Rs16147 TT homozygotes had higher body weight and a greater increase in sum of 5 skinfolds, waist circumference, WHR and waist-to-height ratio; however, they had lower carbohydrate intake throughout the observation period. Rs16147 TT-homozygotes and both rs16139 and rs17149106 heterozygotes had higher triglyceride levels. All NPY SNP-s were associated with blood pressure: rs5574 TT-and rs16147 CC-homozygotes had a smaller increase in diastolic blood pressure, while rs16139 and rs17149106 heterozygous had lower blood pressure throughout the study. Conclusion: Variants of the NPY gene were associated with measures of obesity, dietary intake, glucose and lipid metabolism and blood pressure from adolescence to young adulthood.	et
dc.identifier.uri	https://doi.org/10.1016/j.peptides.2021.170524
dc.identifier.uri	http://hdl.handle.net/10062/71637
dc.language.iso	eng	et
dc.publisher	Elsevier
dc.relation	info:eu-repo/grantAgreement/EC/H2020/667302///CoCA	et
dc.relation	info:eu-repo/grantAgreement/EC/H2020/728018///Eat2beNICE
dc.rights	info:eu-repo/semantics/openAccess	et
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	neuropeptide Y	et
dc.subject	obesity	et
dc.subject	dietary intake	et
dc.subject	blood pressure	et
dc.subject	glucose metabolism	et
dc.subject	lipid metabolism	et
dc.title	Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: a longitudinal birth cohort study	et
dc.type	info:eu-repo/semantics/article	et