Browsing WIDENLIFE - Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing by Issue Date

Now showing items 1-20 of 45

    • A novel hypothesis for histone-to-protamine transition in Bos taurus spermatozoa 

      Sillaste, Gerly; Kaplinski, Lauris; Meier, Riho; Jaakma, Ülle; Eriste, Elo; Salumets, Andres (2016)
      DNA compaction with protamines in sperm is essential for successful fertilization. However, a portion of sperm chromatin remains less tightly packed with histones, which genomic location and function remain unclear. We ...

    • Demographic associations for autoantibodies in disease-free individuals of a European population 

      Haller-Kikkatalo, Kadri; Alnek, Kristi; Metspalu, Andres; Mihailov, Evelin; Metsküla, Kaja; Kisand, Kalle; Pisarev, Heti; Salumets, Andres; Uibo, Raivo (2016)
      The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals ...

    • Globin mRNA reduction for whole-blood transcriptome sequencing 

      Krjutškov, Kaarel; Koel, Mariann; Roost, Anne Mari; Katayama, Shintaro; Einarsdottir, Elisabet; Jouhilahti, Eeva-Mari; Söderhäll, Cilla; Jaakma, Ülle; Plaas, Mario; Vesterlund, Liselotte; Lohi, Hannes; Salumets, Andres; Kere, Juha (Scientific Reports, 2016)
      The transcriptome analysis of whole-blood RNA by sequencing holds promise for the identification and tracking of biomarkers; however, the high globin mRNA (gmRNA) content of erythrocytes hampers whole-blood and buffy coat ...

    • Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis 

      Aghajanova, Lusine; Altmäe, Signe; Kasvandik, Sergo; Salumets, Andres; Stavreus-Evers, Anneli; Giudice, Linda C. (2016)
      Objective To determine expression of stanniocalcin-1 (STC1) in human endometrium with and without endometriosis and its regulation by steroid hormones. Design Laboratory study. Setting University. Patient(s) Nineteen ...

    • The influence of menstrual cycle and endometriosis on endometrial methylome 

      Saare, Merli; Modhukur, Vijayachitra; Suhorutshenko, Marina; Rajashekar, Balaji; Rekker, Kadri; Sõritsa, Deniss; Karro, Helle; Soplepmann, Pille; Sõritsa, Andrei; Lindgren, Cecilia M; Rahmioglu, Nilufer; Drong, Alexander; Becker, Christian M; Zondervan, Krina T; Salumets, Andres; Peters, Maire (Clin Epigenetics, 2016-01)
      BACKGROUND: Alterations in endometrial DNA methylation profile have been proposed as one potential mechanism initiating the development of endometriosis. However, the normal endometrial methylome is influenced by the cyclic ...

    • Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues 

      Pervjakova, Natalia; Kasela, Silva; Morris, Andrew P; Kals, Mart; Metspalu, Andres; Lindgren, Cecilia M; Salumets, Andres; Mägi, Reedik (Epigenomics, 2016-03)
      Genomic imprinting is an epigenetic feature characterized by parent-specific monoallelic gene expression. The aim of this study was to compare the DNA methylation status of imprinted genes and imprinting control regions ...

    • Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond 

      Laisk-Podar, Triin; Lindgren, Cecilia M.; Peters, Maire; Tapanainen, Juha S.; Lambalk, Cornelis B.; Salumets, Andres; Mägi, Reedik (2016-05)
      Ovarian function is central to female fertility, and several genome-wide association studies (GWAS) have been carried out to elucidate the genetic background of traits and disorders that reflect and affect ovarian physiology. ...

    • Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases 

      Tšuiko, O.; Nõukas, M.; Žilina, O.; Hensen, K.; Tapanainen, J.; Mägi, R.; Kals, M.; Kivistik, PA.; Haller-Kikkatalo, K.; Salumets, A.; Kurg, A. (2016-06)
      STUDY QUESTION Can spontaneous premature ovarian failure (POF) patients derived from population-based biobanks reveal the association between copy number variations (CNVs) and POF? SUMMARY ANSWER CNVs can hamper the ...

    • Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form 

      Boggavarapu, Nageswara Rao; Lalitkumar, Sujata; Joshua, Vijay; Kasvandik, Sergo; Salumets, Andres; Lalit Kumar, Parameswaran Grace; Gemzell-Danielsson, Kristina (2016-09)
      The complexity of endometrial receptivity at the molecular level needs to be explored in detail to improve the management of infertility. Here, differential expression of transcriptomes in receptive endometrial glands and ...

    • C14orf132 gene is possibly related to extremely low birth weight 

      Tiirats, Airi; Viltrop, Triin; Nõukas, Margit; Reimann, Ene; Salumets, Andres; Kõks, Sulev (2016-09)
      Background Despite extensive research the genetic component of extremely low birth weight (ELBW) in newborns has remained obscure. Results The aim of the case study was to identify candidate gene(s) causing ELBW in newborns ...

    • High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium 

      Rekker, Kadri; Saare, Merli; Eriste, Elo; Tasa, Tõnis; Kukuškina, Viktorija; Roost, Anne Mari; Anderson, Kristi; Samuel, Kadri; Karro, Helle; Salumets, Andres; Peters, Maire (2017)
      The aetiology of endometriosis is still unclear and to find mechanisms behind the disease development, it is important to study each cell type from endometrium and ectopic lesions independently. The objective of this study ...

    • Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions 

      Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; GIANT Consortium; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Göran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Kilpeläinen, Tuomas O.; Scott, Robert A.; Mägi, Reedik; Paré, Guillaume; Franks, Paul W.; Ridker, Paul M.; Wareham, Nicholas J.; Ong, Ken K.; Loos, Ruth J. F.; Chasman, Daniel I.; Ingelsson, Erik (2017)
      Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and ...

    • The management of menopause in women with a history of endometriosis: a systematic review 

      Gemmell, L.C.; Webster, K.E.; Kirtley, S.; Vincent, K.; Zondervan, K.T.; Becker, C.M. (2017)
      BACKGROUND Endometriosis is typically regarded as a premenopausal disease, resolving after natural or iatrogenic menopause due to declining oestrogen levels. Nonetheless, case reports over the years have highlighted the ...

    • Genome stability of bovine in vivo-conceived cleavage-stage embryos is higher compared to in vitro-produced embryos. 

      Tšuiko, Olga; Catteeuw, Maaike; Zamani Esteki, Masoud; Destouni, Aspasia; Bogado Pascottini, Osvaldo; Besenfelder, Urban; Havlicek, Vitezslav; Smits, Katrien; Kurg, Ants; Salumets, Andres; D’Hooghe, Thomas; Voet, Thierry; Van Soom, Ann; Vermeesch, Joris Robert (2017)
      STUDY QUESTION Is the rate and nature of chromosome instability (CIN) similar between bovine in vivo-derived and in vitro-cultured cleavage-stage embryos? SUMMARY ANSWER There is a major difference regarding chromosome ...

    • Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues. 

      Rahmioglu, N.; Drong, AW.; Lockstone, H.; Tapmeier, T.; Hellner, K.; Saare, M.; Laisk-Podar, T.; Dew, C.; Tough, E.; Nicholson, G.; Peters, M.; Morris, AP.; Lindgren, CM.; Becker, CM.; Zondervan, KT. (2017)
      Genome-wide association studies in the fields of reproductive medicine and endocrinology are yielding robust genetic variants associated with disease. Integrated genomic, transcriptomic, and epigenomic molecular profiling ...

    • Challenges in endometriosis miRNA studies - From tissue heterogeneity to disease specific miRNAs. 

      Saare, Merli; Rekker, Kadri; Laisk-Podar, Triin; Rahmioglu, Nilufer; Zondervan, Krina; Salumets, Andres; Götte, Martin; Peters, Maire (2017)
      In order to uncover miRNA changes in endometriosis pathogenesis, both endometriotic lesions and endometrial biopsies, as well as stromal and epithelial cells isolated from these tissues have been investigated and a large ...

    • DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase 

      Kukushkina, V.; Modhukur, V.; Suhorutšenko, M.; Peters, M.; Mägi, R.; Rahmioglu, N.; Velthut-Meikas, A.; Altmäe, S.; Esteban, FJ.; Vilo, J.; Zondervan, K.; Salumets, A.; Laisk-Podar, T. (2017)
      The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although not much is known about the endometrial ...

    • Principles guiding embryo selection following genome-wide haplotyping of preimplantation embryos. 

      Dimitriadou, E.; Melotte, C.; Debrock, S.; Esteki, MZ.; Dierickx, K.; Voet, T.; Devriendt, K.; de Ravel, T.; Legius, E.; Peeraer, K.; Meuleman, C.; Vermeesch, JR. (2017)
      STUDY QUESTION How to select and prioritize embryos during PGD following genome-wide haplotyping? SUMMARY ANSWER In addition to genetic disease-specific information, the embryo selected for transfer is based on ranking ...

    • Determination of biological activity of gonadotropins hCG and FSH by Förster resonance energy transfer based biosensors 

      Mazina, Olga; Allikalt, Anni; Tapanainen, Juha S.; Salumets, Andres; Rinken, Ago (2017)
      Determination of biological activity of gonadotropin hormones is essential in reproductive medicine and pharmaceutical manufacturing of the hormonal preparations. The aim of the study was to adopt a G-protein coupled ...

    • The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota 

      Drell, Tiina; Štšepetova, Jelena; Simm, Jaak; Rull, Kristiina; Aleksejeva, Aira; Antson, Anne; Tillmann, Vallo; Metsis, Madis; Sepp, Epp; Salumets, Andres; Mändar, Reet (2017)
      Very few studies have analyzed how the composition of mother’s microbiota affects the development of infant’s gut and oral microbiota during the first months of life. Here, microbiota present in the mothers’ gut, vagina, ...