Sirvi Autor "Reimand, Koit" järgi

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Autoimmunity in reproductive failure: a study on associated autoantibodies and autoantigens
(2010-05-07T12:20:33Z) Reimand, Koit
Infertility, biological inability of a person to contribute to conception, refers also to a couple unable to achieve pregnancy after one year of trying. Infertility touches, for a shorter or longer period, 10-15% of couples and is caused by a variety of different diseases and conditions. Autoimmunity – immune reactions targeted against self biomolecules – is shown to be involved in some certain cases of male as well as female infertility; some types of autoantibodies are in various ways related to reproductive failure. However, many corresponding autoantigens are still not identified. Furthermore, there is a kind of controversial data about the significance of the presence of certain autoantibodies in reproductive failure. This study focused on (i) characterizing common autoantibodies as a circumstantial evidence for an involvement of autoimmunity in female infertility; (ii) clarifying the situation of autoantigenic targets in female hypogonadism associated with premature ovarian failure (POF) and autoimmune polyendocrine syndrome type 1 (APS-1); (iii) finding out new testicular autoantigens besides the known ones concerning male gonadal failure and infertility. The study revealed that the non-organ-specific common autoantibodies (ANA and SMA types) are significantly more prevalent among female patients with infertility than among women of general population. Although this prevalence might be due to a variety of causes, the incidence strongly supports the argument for autoimmune reactions being involved in some cases of female infertility. Secondly, 3βHSD autoantibodies, reported as POF-associated (with 21% prevalence), appear to be seldom (prevalence 2.4%) in case of these patients. Therefore their significance as a single diagnostic biomarker for POF is modest. Thirdly, a testis-expressed protein TSGA10 reveals as an autoantigen by human testis cDNA library immunoscreening with APS-1 male patients sera. A few (7%) APS-1 male and female patients’ sera contained TSGA10 autoantibodies but without any clinical association with gonadal failure in these patients. These autoantibodies persist in an APS-1 male patient sera during 25 years follow up. However, the significance of TSGA10 autoreactivity in APS-1 remains indistinct.
Immunoloogia
(Tartu Ülikooli Kirjastus, 2024-11-28) Uibo, Raivo; Kisand, Kalle; Peterson, Pärt; Reimand, Koit
Käesolev eestikeelne immunoloogiaõpik on tänapäevastatud versioon 2015. a ilmunud õpikust. Uue õpikuteksti kirjutamise vajaduse tingis immunoloogiateaduse ja selle meditsiiniliste rakendusvõimaluste kiire areng viimastel aastatel. Seetõttu sai autoritele oluliseks küsimuseks, mida uues versioonis kajastada ja mida mitte. Arusaadavalt on need valikud rasked, eriti kui arvestada neid mitmekesiseid teadmisi, mida on saadud uute nakkushaiguste (COVID-19 jt) immuunmehhanismide uuringutes. Kiiresti on suurenenud ka immunoregulatoorsete protsesside teaduslike andmete hulk. Tänu immuunsüsteemi kontrollpunktide mõjutamisel saadud kliiniliste uuringute tulemustele on avanenud uued võimalused kasvajate raviks. Näiteid viimase ligemale kümne aasta saavutustest immunoloogias võib tuua rohkelt ning seda kõike püüdsid autorid uues õpikuversioonis ka tasakaalustatult kajastada. Käesolevas väljaandes on mitmeid uusi jooniseid, tabeleid jm, mis peaksid lugemist hõlbustama.