Browsing by Author "Ringmets, Inge"

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Association of FTO rs1421085 with obesity, diet, physical activity and socioeconomic status: a longitudinal birth cohort study
(2020) Katus, Urmeli; Villa, Inga; Ringmets, Inge; Vaht, Mariliis; Mäestu, Evelin; Mäestu, Jarek; Veidebaum, Toomas; Harro, Jaanus
Background and aims Fat mass and obesity-associated protein (FTO) variants are among genetic variants frequently associated with obesity. We analyzed the association between FTO rs1421085 polymorphism and obesity, dietary intake, cardiorespiratory fitness (CRF), physical activity, and socioeconomic status (SES) from the age of 9–25 years. Methods and results The sample included both birth cohorts (originally n = 1176) of the Estonian Children Personality Behaviour and Health Study. The association between FTO rs1421085 and obesity, dietary intake, CRF, physical activity, and SES from the age of 15–25 years was assessed using linear mixed-effects regression models. Associations at ages 9 (younger cohort only), 15, 18, and 25 years were assessed by one-way ANOVA. Male C-allele carriers had significantly (p < 0.05) higher body mass index (BMI), sum of 5 skinfolds, body fat percentage, and hip circumference from the age of 15–25 years. Findings were similar at the age of 9 years. In female subjects, waist-to-hip ratio was significantly greater in CC homozygotes. Interestingly, female CC homozygotes had a greater decrease in the rate of change in daily energy intake and lipid intake per year and higher physical activity score at every fixed time point. Moreover, in females, an effect of FTO × SES interaction on measures of obesity was observed. Conclusion The FTO rs1421085 polymorphism was associated with obesity and abdominal obesity from childhood to young adulthood in males, and with abdominal obesity from adolescence to young adulthood in females. This association is rather related to differences in adipocyte energy metabolism than lifestyle.
Eesti naiste tervis 2014: seksuaal-ja reproduktiivtervis, tervisekäitumine, hoiakud ja tervishoiuteenuste kasutamine: uurimisaruanne
(Tartu, 2015) Lippus, Hedda; Laanpere, Made; Part, Kai; Ringmets, Inge; Rahu, Mati; Haldre, Kai; Allvee, Kärt; Karro, Helle; Tartu Ülikool. Naistekliinik
Kehavälise viljastamise efektiivsus ja kulud Eestis: tervisetehnoloogia hindamise raport TTH04
(2013) Tonsiver, Telvi; Ehrenberg, Aivar; Ringmets, Inge; Saare, Kadre; Lepik, Kristiina; Kiivet, Raul-Allan; Tartu Ülikool. Tervishoiu instituut
Kirurgiline ravi Eestis: kuus operatsiooni arvudes
(Tartu, 2019) Kiivet, Raul-Allan; Pisarev, Heti; Ringmets, Inge; et al; Tartu Ülikool. Peremeditsiini ja rahvatervishoiu instituut
Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: a longitudinal birth cohort study
(Elsevier, 2021) Katus, Urmeli; Villa, Inga; Ringmets, Inge; Veidebaum, Toomas; Harro, Jaanus
Objective: Neuropeptide Y affects several physiological functions, notably appetite regulation. We analysed the association between four single nucleotide polymorphisms (SNP) in the NPY gene (rs5574, rs16147, rs16139, rs17149106) and measures of obesity, dietary intake, physical activity, blood pressure, glucose and lipid metabolism from adolescence to young adulthood. Methods: The sample included both birth cohorts of the Estonian Children Personality Behaviour and Health Study at ages 15 (n = 1075 with available complete data), 18 (n = 913) and 25 (n = 926) years. Linear mixed-effects regression models were used for longitudinal association between NPY SNP-s and variables of interest. Associations at ages 15, 18 and 25 were analysed by ANOVA. Results: Rs5574 CC-homozygotes had a greater increase per year in waist-to-hip ratio (WHR) and a smaller decrease in daily energy intake and carbohydrate intake from age 15 to 25 years; fasting glucose and cholesterol were higher in rs5574 CC-homozygotes. Rs16147 TT homozygotes had higher body weight and a greater increase in sum of 5 skinfolds, waist circumference, WHR and waist-to-height ratio; however, they had lower carbohydrate intake throughout the observation period. Rs16147 TT-homozygotes and both rs16139 and rs17149106 heterozygotes had higher triglyceride levels. All NPY SNP-s were associated with blood pressure: rs5574 TT-and rs16147 CC-homozygotes had a smaller increase in diastolic blood pressure, while rs16139 and rs17149106 heterozygous had lower blood pressure throughout the study. Conclusion: Variants of the NPY gene were associated with measures of obesity, dietary intake, glucose and lipid metabolism and blood pressure from adolescence to young adulthood.
Tervishoiu kvaliteedisüsteemi arendamine: III etapp. Ettevalmistustööd kvaliteedisüsteemi arendamiseks ja kvaliteediindikaatorite rakendamissüsteemi väljatöötamine
(Tartu, 2015) Kiivet, Raul-Allan; Kalda, Ruth; Petersen, Mari; Ringmets, Inge; Themas, Elvo; Tartu Ülikool. Tervishoiu instituut
The role of reward sensitivity in obesity and its association with Transcription Factor AP2B: a longitudinal birth cohort study
(Elsevier, 2020) Katus, Urmeli; Villa, Inga; Ringmets, Inge; Pulver, Aleksander; Veidebaum, Toomas; Harro, Jaanus
Objective One factor potentially contributing to obesity is reward sensitivity. We investigated the association between reward sensitivity and measures of obesity from 9–33 years of age, paying attention to the inner structure of reward sensitivity. Methods The sample included both birth cohorts (originally n = 1176) of the Estonian Children Personality Behaviour and Health Study. The association between reward sensitivity and measures of obesity was assessed using mixed-effects regression models. Associations at ages 9 (younger cohort only), 15, 18, 25 and 33 (older cohort) years were analyzed by one-way ANOVA. The indirect effect of the gene encoding transcription factor 2 beta (TFAP2B) on obesity through reward sensitivity was tested using mediation analysis. Results According to linear mixed effects regression models, an increase in scores of Insatiability by Reward and both of its components, Excessive Spending and Giving in to Cravings, significantly increased body weight, body mass index, sum of five skinfolds, waist circumference, hip circumference and waist-to-height ratio from 15 to 25 years of age. Findings were similar at age 9 and 33 years. In contrast, no association between obesity and Openness to Rewards or its facets was observed. The TFAP2B genotype was also associated with fixation to rewards in females, but not with striving towards reward multiplicity. Conclusion Our results suggest that reward sensitivity is associated with obesity by its reward fixation component. The heterogeneity of the reward sensitivity construct should be taken into account in studies on body composition.