Sirvi Autor "Tamm, Andres" järgi

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Soovitusliku Tööstus 4.0 teekaardi loomine Eesti mehhatroonika- ja masinatööstuse ettevõtetele
(Tartu Ülikool, 2017) Tamm, Andres; Varblane, Urmas, juhendaja; Riives, Jüri, kaasjuhendaja; Tartu Ülikool. Majandusteaduskond; Tartu Ülikool. Sotsiaalteaduste valdkond
Too much alcohol, different gene surface? Alcohol abuse could be associated with monoamine oxidase A gene methylation
(Tartu Ülikool, 2014) Tamm, Andres; Harro, Jaanus, juhendaja; Tartu Ülikool. Sotsiaal- ja haridusteaduskond; Tartu Ülikool. Psühholoogia instituut
Monoamine oxidase A (MAO-A) is an enzyme that metabolizes neurotransmitters involved in alcohol dependency. To investigate if MAO-A is associated with alcohol abuse, I compared MAOA gene methylation in males with or without alcohol use disorders (N = 24 and N = 55, respectively). Methylation of MAOA gene in white blood cells was used as an index of MAO-A activity in the brain. Average methylation was higher in males with alcohol use disorders (AUD), but only in the nonsmokers’ subsample (Wilcoxon p = 0.01, proportion of better responses = 0.86). Methylation at gene site CpG10 was also higher in nonsmokers with AUD (p = 0.05, proportion = 0.80). Interaction between smoking and methylation is a novel finding. Because the sample of nonsmokers is small (N = 5 + 19), these results should be considered only as initial.