Sirvi Kuupäev , alustades "2009-10-01T12:42:28Z" järgi

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Etiopathogenetic aspects of chronic prostatitis: role of mycoplasmas, coryneform bacteria and oxidative stress
(2009-10-01T12:42:28Z) Türk, Silver
The dissertation elucidates the causes and mechanisms behind chronic prostatitis. Of potential causes, the dissertation focuses upon mycoplasmas and coryneform bacteria that are not detected during routine analyses. Of disease mechanisms, the dissertation focuses upon oxidative stress, a likely propagator of the disease. Coryneforms form an important part of urogenital polymicrobial community in both healthy men and prostatitis patients but in patients a clearly wider spectrum of the species is present in the urogenital tract. Urogenital tract coryneforms are often resistant to clindamycin, erythromycin, nitrofurantoin, tetracyclin and common anti-prostatitis drug norfloxacin while these bacteria were always or virtually always susceptible to penicillins and TMP/SMX. There were differences in species composition of mycoplasmas as well. The species that most clearly associated with prostatitis were Ureaplasma parvum and Corynebacterium group G. In prostatitis patients, oxidative stress is present both locally and systemically and it consists of not only increased levels of oxidation products and pro-oxidants but reduced antioxidant levels as well. In the discussion part of the dissertation, there is a proposed scheme of pathogenesis where oxidative stress is used to tie the well-known pathogenetic mechanisms (infectious, autoimmune and neuromuscular) together into a pathogenetic circle.