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Demographic associations for autoantibodies in disease-free individuals of a European population

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Date
2016
Author
Haller-Kikkatalo, Kadri
Alnek, Kristi
Metspalu, Andres
Mihailov, Evelin
Metsküla, Kaja
Kisand, Kalle
Pisarev, Heti
Salumets, Andres
Uibo, Raivo
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Abstract
The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto)immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
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https://doi.org/10.1038/srep44846
http://hdl.handle.net/10062/63411
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  • WIDENLIFE - Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing [45]

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