Acylation of N-Boc-N’-COCF3 protected hydrazine

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dc.contributor.advisorMastitski,Anton, juhendaja
dc.contributor.authorKurbanova, Karina
dc.contributor.otherTartu Ülikool. Loodus- ja täppisteaduste valdkond
dc.contributor.otherTartu Ülikool. Tehnoloogiainstituut
dc.date.accessioned2024-06-18T10:00:52Z
dc.date.available2024-06-18T10:00:52Z
dc.date.issued2024
dc.description.abstractWithin the scope of the present thesis acylation of N-Boc-N’-COCF3 protected hydrazine was investigated. Acetic anhydride, benzoyl and butanoyl chlorides, activated esters and benzyl chloroformate were tested as acylating agents. The implementation of highly reactive acyl chlorides led to very good yields of hydrazines monoacylated at the Boc-protected nitrogen. Application of an excess of acyl chlorides promoted the formation of diacylated Boc-protected hydrazines and an unexpected loss of the trifluoroacetic group. Acylation by activated esters or benzyl chloroformate resulted solely in monoacylated products isolated in fair to poor yields. Reactions utilizing acetic anhydride gave no product irrespective of reaction conditions.
dc.identifier.urihttps://hdl.handle.net/10062/99946
dc.language.isoen
dc.publisherTartu Ülikool
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Estoniaen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/ee/
dc.subjectHydrazine
dc.subjectAcylation
dc.subjectOrthogonal protecting groups
dc.subject.otherbakalaureusetöödet
dc.titleAcylation of N-Boc-N’-COCF3 protected hydrazine
dc.title.alternativeN-Boc-N’-COCF3 kaitstud hüdrasiini atsüülimine
dc.typeThesis

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Science and Technology - Bachelor's theses. Kuni 2024