Association of FTO rs1421085 with obesity, diet, physical activity and socioeconomic status: a longitudinal birth cohort study

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dc.contributor.authorKatus, Urmeli
dc.contributor.authorVilla, Inga
dc.contributor.authorRingmets, Inge
dc.contributor.authorVaht, Mariliis
dc.contributor.authorMäestu, Evelin
dc.contributor.authorMäestu, Jarek
dc.contributor.authorVeidebaum, Toomas
dc.contributor.authorHarro, Jaanus
dc.date.accessioned2020-05-14T12:34:07Z
dc.date.available2020-05-14T12:34:07Z
dc.date.issued2020
dc.description.abstractBackground and aims Fat mass and obesity-associated protein (FTO) variants are among genetic variants frequently associated with obesity. We analyzed the association between FTO rs1421085 polymorphism and obesity, dietary intake, cardiorespiratory fitness (CRF), physical activity, and socioeconomic status (SES) from the age of 9–25 years. Methods and results The sample included both birth cohorts (originally n = 1176) of the Estonian Children Personality Behaviour and Health Study. The association between FTO rs1421085 and obesity, dietary intake, CRF, physical activity, and SES from the age of 15–25 years was assessed using linear mixed-effects regression models. Associations at ages 9 (younger cohort only), 15, 18, and 25 years were assessed by one-way ANOVA. Male C-allele carriers had significantly (p < 0.05) higher body mass index (BMI), sum of 5 skinfolds, body fat percentage, and hip circumference from the age of 15–25 years. Findings were similar at the age of 9 years. In female subjects, waist-to-hip ratio was significantly greater in CC homozygotes. Interestingly, female CC homozygotes had a greater decrease in the rate of change in daily energy intake and lipid intake per year and higher physical activity score at every fixed time point. Moreover, in females, an effect of FTO × SES interaction on measures of obesity was observed. Conclusion The FTO rs1421085 polymorphism was associated with obesity and abdominal obesity from childhood to young adulthood in males, and with abdominal obesity from adolescence to young adulthood in females. This association is rather related to differences in adipocyte energy metabolism than lifestyle.et
dc.identifier.urihttps://doi.org/10.1016/j.numecd.2020.02.008
dc.identifier.urihttp://hdl.handle.net/10062/67363
dc.language.isoenget
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/667302///CoCAet
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/728018///Eat2beNICE
dc.relation.ispartofseriesNutrition, Metabolism and Cardiovascular Diseases;
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectFTO rs1421085et
dc.subjectobesityet
dc.subjectdietet
dc.subjectcardiorespiratory fitnesset
dc.subjectphysical activityet
dc.subjectsocioeconomic statuset
dc.titleAssociation of FTO rs1421085 with obesity, diet, physical activity and socioeconomic status: a longitudinal birth cohort studyet
dc.typeinfo:eu-repo/semantics/articleet

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Eat2beNICE — Toitumise ja eluviisi mõju impulsiivsele, kompulsiivsele ja eksternaliseeritud käitumisele / Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing Behaviours
CoCA — Aktiivsus-tähelepanuhäirega koosesinevad haigused ja tervisehäired / Comorbid Conditions of Attention Deficit/Hyperactive Disorders