Low cholesterol levels in children predict impulsivity in young adulthood

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dc.contributor.authorTomson-Johanson, Katrin
dc.contributor.authorKaart, Tanel
dc.contributor.authorKiivet, Raul-Allan
dc.contributor.authorVeidebaum, Toomas
dc.contributor.authorHarro, Jaanus
dc.date.accessioned2019-11-11T13:55:32Z
dc.date.available2019-11-11T13:55:32Z
dc.date.issued2019
dc.description.abstractObjective: Severe behavioural issues such as impulsive action and suicide have since long been associated with low levels of cholesterol. While it is known that cholesterol plays a role in neural development and hence low levels of serum lipids could have long-term effects on behaviour, there are no longitudinal studies showing association of serum lipids levels with impulsivity. We aimed to examine the prognostic properties of serum lipid levels during childhood and adolescence on measures of impulsivity during early adulthood in a representative birth cohort sample. Methods: We have investigated whether serum lipid levels measured at 9, 15, 18 and 25 years of age have an association with impulsivity in 25 years old young adults. This analysis was based on data of the birth cohort representative samples of the Estonian Children Personality Behaviour and Health Study (original n=1238). Impulsivity was self-reported with the Adaptive and Maladaptive Impulsivity Scale. Results: Total and LDL cholesterol measured in 9, 15 and 18 years old boys predicted Disinhibition and Thoughtlessness in 25 years old young adults. High scores of Disinhibition were associated with low total and LDL cholesterol levels in males but, while less consistently, with high total and LDL cholesterol levels in females. Cross-sectional analysis did not result in systematic outcomes. Conclusions: Serum lipid levels could have an impact on development of maladaptive impulsivity starting from an early age. This effect of cholesterol continues throughout adolescence into young adulthood.et
dc.identifier.urihttp://hdl.handle.net/10062/66598
dc.language.isoenget
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/667302///CoCAet
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/728018///Eat2beNICE
dc.relation.ispartofseriesActa Neuropsychiatrica;
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectCholesterolet
dc.subjectImpulsivityet
dc.subjectChildrenet
dc.subjectYoung adultset
dc.subjectSexet
dc.titleLow cholesterol levels in children predict impulsivity in young adulthoodet
dc.typeinfo:eu-repo/semantics/articleet

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CoCA — Aktiivsus-tähelepanuhäirega koosesinevad haigused ja tervisehäired / Comorbid Conditions of Attention Deficit/Hyperactive Disorders
Eat2beNICE — Toitumise ja eluviisi mõju impulsiivsele, kompulsiivsele ja eksternaliseeritud käitumisele / Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing Behaviours