Investigating properties of wildtype and mutant Barmah Forest virus replicases

dc.contributor.author	Oduware, Evelyn Osayimwense
dc.date.accessioned	2021-06-29T09:40:53Z
dc.date.available	2021-06-29T09:40:53Z
dc.date.issued	2021
dc.description.abstract	Barmah Forest virus (BFV) is an alphavirus that is mostly spread in Australia and it causes disease in humans upon infection that may manifest as arthritis, myalgia, fever and rash. For this reason, BFV is a cause for concern in puclic health and often a subject in alphavirus related research. In the current work, we observed that BFV replicase activates the type I IFN response in the absence of a viral template, and that mutations in viral replicase proteins may boost IFN production. Furthermore, we looked into the effect that these mutations may possess on the replication and transcription of the BFV replicase using the trans-complementation system. These experiments aid in understanding how alphaviruses influence host cells and vice versa, which could provide useful information in the research for antiviral agents.	et
dc.identifier.uri	http://hdl.handle.net/10062/72763
dc.language.iso	eng	et
dc.rights	openAccess	et
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Alphavirus	et
dc.subject	Barmah Forest virus	et
dc.subject	BFV replicase	et
dc.subject	alphavirus non-structural proteins	et
dc.title	Investigating properties of wildtype and mutant Barmah Forest virus replicases	et
dc.type	Thesis	et

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