The role of TREM2 protein in skin fibroblast and keratinocyte proliferation and migration
| dc.contributor.author | Linno, Kirke | |
| dc.date.accessioned | 2021-06-29T09:12:56Z | |
| dc.date.available | 2021-06-29T09:12:56Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Skin is the first physical barrier of the body as it protects the body from external environment and lets the organism to sense pain, touch and temperature. Therefore, it is important to restore the skin as quicky as possible after damage. This research project aimed to investigate whether the protein Triggering receptor expressed on myeloid cells-2 (TREM2) contributes to skin fibroblast and keratinocyte proliferation and migration that could potentially promote wound healing. The expression of TREM2 in human skin was characterized and the effect of soluble recombinant TREM2 protein in cell proliferation and migration were investigated. It was found that TREM2 is expressed in the dermis and in extracellular matrix of dermis of healthy human skin, but it probably inhibits cell proliferation and has no overall effect on the migration of the cells. | et |
| dc.identifier.uri | http://hdl.handle.net/10062/72756 | |
| dc.language.iso | eng | et |
| dc.rights | openAccess | et |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | skin | et |
| dc.subject | migration | et |
| dc.subject | proliferation | et |
| dc.subject | fibroblasts | et |
| dc.subject | keratinocytes | et |
| dc.subject | TREM2 | et |
| dc.title | The role of TREM2 protein in skin fibroblast and keratinocyte proliferation and migration | et |
| dc.type | Thesis | et |