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Immune markers in major depression and in antidepressive treatment
(2009-11-20T11:34:01Z) Eller, Triin
The purposes of this study were to find associations between depression, depressive symptoms and soluble interleukine- 2 receptor (sIL-2R), tumour necrosis factor-α (TNF-α) and anti thyroid peroxidise auto-antibodies (anti-TPO). We investigated the acute and chronic effects of selective serotonin re-uptake inhibitor, escitalopram, alone and in combination with bupropion on serum levels of interleukin-8 (IL-8), sIL-2R and TNFα in patients with major depression. In addition, we explored whether serum cytokine concentrations and/or anti-TPO positivity can predict treatment response to antidepressants. The levels of TNF-α were lower in currently depressed subjects compared with euthymic subjects in the study cohort. MDD patients with previous antidepressive treatment had significantly lower levels of TNF-α than drug-naïve patients and HC. There were different patterns of changes in the levels of sIL-2R in responders and non-responders to escitalopram treatment. Treatment with escitalopram had no significant effect on the levels of IL-8 and TNF-α. Augmentation of escitalopram treatment with bupropion caused a significant increase in IL-8 serum concentrations during 6 weeks of augmentation therapy. There was no effect on the levels of sIL-2R and TNF-α. The lower baseline TNF-α level was found in the responder group in the escitalopram treatment phase. There was a trend for higher frequency of baseline anti-TPO positive cases in female non-responders to escitalopram monotherapy as compared with responders. There were no significant differences in the levels of thyroid hormones (particularly, total T3, free T3, freeT4, and TSH) between female responders and non-responders.