Sirvi Autor "Tran, Vi Ngan, juhendaja" järgi

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Development of new tools for live imaging of BMP signalling in the Drosophila melanogaster wing
(Tartu Ülikool, 2020) Pau, Robin; Shimmi, Osamu, juhendaja; Tran, Vi Ngan, juhendaja; Tõnissoo, Tambet, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Molekulaar- ja rakubioloogia instituut
BMP signalling pathway has a central part in animal development. It is responsible for many different functions during animal development including cell proliferation, adult tissue homeostasis, apoptosis, early axial patterning. To study the dynamics of BMP signalling new and more precise tools are needed. During this bachelor’s thesis, a LlamaTag based tool was created. Which can be used to observe BMP signalling pathway protein Mothers against Dpp (Mad) movement in vivo in fruit fly Drosophila melanogaster using live imaging method.
Live Imaging of Drosophila melanogaster Eye-Antennal Imaginal Disc Ex vivo Culture: Craniofacial Morphogenesis
(Tartu Ülikool, 2024) Sarv, Robin; Shimmi, Osamu, juhendaja; Tran, Vi Ngan, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Molekulaar- ja rakubioloogia instituut
The ex vivo culture and live imaging of Drosophila larval eye-antennal imaginal discs provide unique insights into the intricate mechanisms of head morphogenesis. We present a refined ex vivo culturing technique optimized for prolonged imaging sessions, during which we defined distinct developmental stages marked by dynamic morphogenetic events, disc fusion, and head cuticle formation. Our investigation reveals the critical role of peripodial epithelium (PE) substructures in mediating fusion events, highlighting their diverse morphological features and functional significance. Additionally, results show that apoptosis, coordinated movement, and fusion of epithelial cells in the imaginal discs are key factors in the morphogenesis of the fly's head region and the formation of head structures.