Development of new tools for live imaging of BMP signalling in the Drosophila melanogaster wing

Abstract

BMP signalling pathway has a central part in animal development. It is responsible for many different functions during animal development including cell proliferation, adult tissue homeostasis, apoptosis, early axial patterning. To study the dynamics of BMP signalling new and more precise tools are needed. During this bachelor’s thesis, a LlamaTag based tool was created. Which can be used to observe BMP signalling pathway protein Mothers against Dpp (Mad) movement in vivo in fruit fly Drosophila melanogaster using live imaging method.