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  •   DSpace @University of Tartu
  • Loodus- ja täppisteaduste valdkond
  • LT Euroopa Liidu rahastatud projektid
  • WIDENLIFE - Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing
  • View Item
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Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond

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Date
2016-05
Author
Laisk-Podar, Triin
Lindgren, Cecilia M.
Peters, Maire
Tapanainen, Juha S.
Lambalk, Cornelis B.
Salumets, Andres
Mägi, Reedik
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Abstract
Ovarian function is central to female fertility, and several genome-wide association studies (GWAS) have been carried out to elucidate the genetic background of traits and disorders that reflect and affect ovarian physiology. While GWAS have been successful in reporting numerous genetic associations and highlighting involved pathways relevant to reproductive aging, for ovarian disorders, such as premature ovarian insufficiency and polycystic ovary syndrome, research has lagged behind due to insufficient study sample size. Novel approaches to study design and analysis methods that help to fit GWAS findings into biological context will improve our knowledge about genetics governing ovarian function in fertility and disease, and provide input for clinical tools and better patient management.
URI
https://doi.org/10.1016/j.tem.2016.04.011
http://hdl.handle.net/10062/63403
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  • WIDENLIFE - Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing [45]

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