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dc.contributor.authorFernàndez-Castillo, Noèlia
dc.contributor.authorGan, Gabriela
dc.contributor.authorM.J. van Donkelaar, Marjolein
dc.contributor.authorVaht, Mariliis
dc.contributor.authorWeber, Heike
dc.contributor.authorRetz, Wolfgang
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorFranke, Barbara
dc.contributor.authorHarro, Jaanus
dc.contributor.authorReif, Andreas
dc.contributor.authorFaraone, Stephen V.
dc.contributor.authorCormand, Bru
dc.date.accessioned2020-05-19T10:41:15Z
dc.date.available2020-05-19T10:41:15Z
dc.date.issued2020
dc.identifier.other10.1016/j.euroneuro.2017.11.012
dc.identifier.urihttp://hdl.handle.net/10062/67385
dc.description.abstractThe RBFOX1 gene (or A2BP1) encodes a splicing factor important for neuronal development that has been related to autism spectrum disorder and other neurodevelopmental phenotypes. Evidence from complementary sources suggests that this gene contributes to aggressive behavior. Suggestive associations with RBFOX1 have been identified in genome-wide association studies (GWAS) of anger, conduct disorder, and aggressive behavior. Nominal association signals in RBFOX1 were also found in an epigenome-wide association study (EWAS) of aggressive behavior. Also, variants in this gene affect temporal lobe volume, a brain area that is altered in several aggression-related phenotypes. In animals, this gene has been shown to modulate aggressive behavior in Drosophila. RBFOX1 has also been associated with canine aggression and is upregulated in mice that show increased aggression after frustration of an expected reward. Associated common genetic variants as well as rare duplications and deletions affecting RBFOX1 have been identified in several psychiatric and neurodevelopmental disorders that are often comorbid with aggressive behaviors. In this paper, we comprehensively review the cumulative evidence linking RBFOX1 to aggression behavior and provide new results implicating RBFOX1 in this phenotype. Most of these studies (genetic and epigenetic analyses in humans, neuroimaging genetics, gene expression and animal models) are hypothesis-free, which strengthens the validity of the findings, although all the evidence is nominal and should therefore be taken with caution. Further studies are required to clarify in detail the role of this gene in this complex phenotype.et
dc.language.isoenget
dc.publisherEur Neuropsychopharmacol.et
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/667302///CoCAet
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectA2BP1et
dc.subjectAggressionet
dc.subjectAnimal modelset
dc.subjectEpigeneticset
dc.subjectGeneticset
dc.subjectTranscriptomicset
dc.subjectNeuroimaginget
dc.subjectRBFOX1et
dc.titleRBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavioret
dc.typeinfo:eu-repo/semantics/articleet


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