Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form

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dc.contributor"European Union (EU)" and "Horizon 2020"
dc.contributor.authorBoggavarapu, Nageswara Rao
dc.contributor.authorLalitkumar, Sujata
dc.contributor.authorJoshua, Vijay
dc.contributor.authorKasvandik, Sergo
dc.contributor.authorSalumets, Andres
dc.contributor.authorLalit Kumar, Parameswaran Grace
dc.contributor.authorGemzell-Danielsson, Kristina
dc.date.accessioned2019-02-26T11:43:21Z
dc.date.available2019-02-26T11:43:21Z
dc.date.issued2016-09
dc.description.abstractThe complexity of endometrial receptivity at the molecular level needs to be explored in detail to improve the management of infertility. Here, differential expression of transcriptomes in receptive endometrial glands and stroma revealed Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a progesterone regulated factor and confirmed by various methods, both at mRNA and protein level. The involvement of ENPP3 in embryo attachment was tested in an in vitro model for human embryo implantation. Interestingly, there was high expression of ENPP3 mRNA in stroma but not protein. Presence of N-glycosylated ENPP3 in receptive phase uterine fluid in women confirms its regulation by progesterone and makes it possible to use in a non-invasive test of endometrial receptivity.et
dc.identifier.urihttps://doi.org/10.1038/srep33811
dc.identifier.urihttp://hdl.handle.net/10062/63406
dc.language.isoenget
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/692065///WIDENLIFEet
dc.relation.ispartofseriesScientific Reports;volume 6, Article number: 33811
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectDiagnostic markerset
dc.subjectInfertilityet
dc.titleCompartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated formet
dc.typeinfo:eu-repo/semantics/articleet

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