Predicting Speci c Protein Abundances and Translation E ciency in Yeast
Date
2020
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Tartu Ülikool
Abstract
Protein abundances and production rates differ by several orders of magnitude
among protein-coding genes. We show that speci c protein abundances can be
modeled as a function of mRNA abundances, translation efficiency and protein
turnover. We then match RNA sequence motifs of 21 RBPs on the untranslated
regions of 774 target transcripts. We determine that the RNA sequence motifs
on target transcripts untranslated regions do not predict variability in translation
efficiency of these transcripts. We use yeast Saccharomyces cerevisiae as the model
organism.
Description
Keywords
linear regression, sequence motifs, RNA-binding proteins, translation efficiency, protein abundance, Saccharomyces cerevisiae