HPV L2 protein derived endosomal escape enhancers
| dc.contributor.author | Mammadova, Sabina | |
| dc.contributor.other | Tartu Ülikool. Loodus- ja täppisteaduste valdkond | et |
| dc.contributor.other | Tartu Ülikool. Tehnoloogiainstituut | et |
| dc.date.accessioned | 2021-07-01T11:39:08Z | |
| dc.date.available | 2021-07-01T11:39:08Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Delivery of macromolecular therapeutics, and specifically their endosomal escape is one of the challenges in the medicine. Although there are several delivery methods developed, there is still a need to overcome the challenges associated with endosomal entrapment. In this work HPV16 L2 protein and peptides derived from this protein were applied for in-creasing transfection efficacy of CPP mediated delivery of nucleic acid. For this, peptides derived from HPV L2 protein specific regions, that are responsible for L2 mediated endo-somal trafficking of viral DNA were tested. Both L2 protein and new synthesised peptides showed promising results for applying them as additives to the CPP/NA nanoparticles for therapeutic use and protein production in the future. | et |
| dc.identifier.uri | http://hdl.handle.net/10062/72923 | |
| dc.language.iso | eng | et |
| dc.publisher | Tartu Ülikool | et |
| dc.rights | embargoedAccess | et |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | protein | et |
| dc.subject | endosomal escape | et |
| dc.subject | transfection | et |
| dc.subject | cell-penetrating peptides | et |
| dc.subject.other | magistritööd | et |
| dc.title | HPV L2 protein derived endosomal escape enhancers | et |
| dc.type | Thesis | et |