HPV L2 protein derived endosomal escape enhancers

dc.contributor.authorMammadova, Sabina
dc.contributor.otherTartu Ülikool. Loodus- ja täppisteaduste valdkondet
dc.contributor.otherTartu Ülikool. Tehnoloogiainstituutet
dc.date.accessioned2021-07-01T11:39:08Z
dc.date.available2021-07-01T11:39:08Z
dc.date.issued2021
dc.description.abstractDelivery of macromolecular therapeutics, and specifically their endosomal escape is one of the challenges in the medicine. Although there are several delivery methods developed, there is still a need to overcome the challenges associated with endosomal entrapment. In this work HPV16 L2 protein and peptides derived from this protein were applied for in-creasing transfection efficacy of CPP mediated delivery of nucleic acid. For this, peptides derived from HPV L2 protein specific regions, that are responsible for L2 mediated endo-somal trafficking of viral DNA were tested. Both L2 protein and new synthesised peptides showed promising results for applying them as additives to the CPP/NA nanoparticles for therapeutic use and protein production in the future.et
dc.identifier.urihttp://hdl.handle.net/10062/72923
dc.language.isoenget
dc.publisherTartu Ülikoolet
dc.rightsembargoedAccesset
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectproteinet
dc.subjectendosomal escapeet
dc.subjecttransfectionet
dc.subjectcell-penetrating peptideset
dc.subject.othermagistritöödet
dc.titleHPV L2 protein derived endosomal escape enhancerset
dc.typeThesiset

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