A Study of Anti-adenoviral activity of antimicrobial peptides

Abstract

Adenoviruses, non-enveloped DNA viruses, pose a significant health concern. This study explores the antiviral potential of four recombinant proteins with attached cationic antimicrobial peptides (H1mod1R, H2mod2R, HELP and HIn) against the human adenovirus (AdV-Gluc) in vitro. The proteins presented some antiviral activity, but this inhibitory effect was independent of the concentrations of the proteins within the tested range. The results are not aligned with the previous research on the cationic antimicrobial peptides with other viruses. Currently, these proteins are not ideal for use as therapeutic against adenovirus, but the good cytotoxicity profile suggests that further research is needed to optimize the efficacy and to explore their mechanism of action for beneficial future applications.