Changes in the levels of DNA methyltransferases and demethylases in the nucleus accumbens in cocaine-induced behavioural sensitisation in rats with different exploratory activity

Simple item page
dc.contributor.advisorHarro, Jaanus, juhendaja
dc.contributor.advisorKalda, Anti, juhendaja
dc.contributor.authorVaher, Kadi
dc.contributor.otherTartu Ülikool. Sotsiaalteaduste valdkondet
dc.contributor.otherTartu Ülikool. Psühholoogia instituutet
dc.date.accessioned2017-06-30T08:18:03Z
dc.date.available2017-06-30T08:18:03Z
dc.date.issued2017
dc.description.abstractEpigenetic modifications, such as DNA methylation, are involved in the development of cocaine-induced behavioural sensitisation. This study investigated the development and expression of cocaine-induced behavioural sensitisation in rats with high and low exploratory activity (HE and LE, respectively), and the drug-induced changes in the mRNA levels of Dnmt and Tet family genes in the nucleus accumbens. Only LE-animals had increased locomotor activity over continuous test sessions in response to repeated cocaine (12 mg/kg) administration and they developed a more pronounced behavioural sensitisation. Repeated cocaine treatment resulted in upregulated mRNA of Dnmt3b in HE-, but not in LE-rats, and upregulated mRNA levels of Tet3 in both. Thus, our results suggest that LE- and HE-rats differ in the development and expression of cocaine-induced behavioural sensitisation. The aim of future research is to further examine, whether the observed changes in Dnmt and Tet levels could explain the behavioural differences between HE- and LE-animals in response to cocaine.en
dc.identifier.urihttp://hdl.handle.net/10062/57051
dc.language.isoengen
dc.publisherTartu Ülikoolet
dc.subjectDNA methyltransferaseen
dc.subjectDNA demethylaseen
dc.subjectcocaineen
dc.subjectbehavioural sensitisationen
dc.subjectnucleus accumbensen
dc.subjectexploratory activityen
dc.subjectDNA metüültransferaaset
dc.subjectDNA demetülaaset
dc.subjectkokaiinet
dc.subjectkäitumuslik sensitisatsioonet
dc.subjectnaalduv tuumet
dc.subjectuudistamisaktiivsuset
dc.subject.otherüliõpilastöödet
dc.titleChanges in the levels of DNA methyltransferases and demethylases in the nucleus accumbens in cocaine-induced behavioural sensitisation in rats with different exploratory activityen
dc.title.alternativeMuutused DNA metüültransferaaside ja demetülaaside tasemetes naalduvas tuumas kokaiini sensitisatsioonil erineva uudistamisaktiivsusega rottidelet
dc.typeThesisen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Vaher_Kadi_uurimistoo.pdf
Size:
1.2 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Psühholoogia instituudi üliõpilastööd – Student works