Too much alcohol, different gene surface? Alcohol abuse could be associated with monoamine oxidase A gene methylation
| dc.contributor.advisor | Harro, Jaanus, juhendaja | |
| dc.contributor.author | Tamm, Andres | |
| dc.contributor.other | Tartu Ülikool. Sotsiaal- ja haridusteaduskond | et |
| dc.contributor.other | Tartu Ülikool. Psühholoogia instituut | et |
| dc.date.accessioned | 2015-02-02T16:01:10Z | |
| dc.date.available | 2015-02-02T16:01:10Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Monoamine oxidase A (MAO-A) is an enzyme that metabolizes neurotransmitters involved in alcohol dependency. To investigate if MAO-A is associated with alcohol abuse, I compared MAOA gene methylation in males with or without alcohol use disorders (N = 24 and N = 55, respectively). Methylation of MAOA gene in white blood cells was used as an index of MAO-A activity in the brain. Average methylation was higher in males with alcohol use disorders (AUD), but only in the nonsmokers’ subsample (Wilcoxon p = 0.01, proportion of better responses = 0.86). Methylation at gene site CpG10 was also higher in nonsmokers with AUD (p = 0.05, proportion = 0.80). Interaction between smoking and methylation is a novel finding. Because the sample of nonsmokers is small (N = 5 + 19), these results should be considered only as initial. | et |
| dc.description.uri | http://www.ester.ee/record=b4453848*est | |
| dc.identifier.uri | http://hdl.handle.net/10062/45247 | |
| dc.language.iso | en | et |
| dc.publisher | Tartu Ülikool | et |
| dc.subject.other | üliõpilastööd | et |
| dc.subject.other | monoamiinoksüdaas | et |
| dc.subject.other | DNA metüülimine | et |
| dc.subject.other | alkoholitarbimine | et |
| dc.title | Too much alcohol, different gene surface? Alcohol abuse could be associated with monoamine oxidase A gene methylation | en |
| dc.type | Thesis | en |