Relationships between genetic and lifestyle factors and weight in the Estonian Biobank

Abstract

The aim of this bachelor’s thesis is to explore relationships between weight and a range of lifestyle and genetic factors. In this study, the genetic factors under consideration are single nucleotide polymorphisms. The analysis is performed on data originating from the Estonian Biobank and focuses on a cohort of slightly over 40 000 gene donors. In addition to identifying associations, emphasis is also placed on quantifying them by finding the effect sizes of relevant factors on weight. To better assess age and gender-specific patterns, the analysis is conducted separately across eight groups, by considering both females and males in the following four age categories: individuals under 30, 30-45, 46-65, and those aged 66 or older. The thesis gives an overview of the necessary theoretical background to enhance understanding of the analysis, introduces the statistical methodology used, then describes the data, and concludes by presenting and discussing the results.