The role of TGFBI in wound healing and skin regeneration

Abstract

The skin is an essential organ of any mammalian organism. It performs many different functions, such as sensory, metabolic, thermoregulatory function, and others. One of the most important functions of the skin is to create a barrier between the body and the environment. Processes such as skin regeneration and wound healing are fundamental to the normal functioning of the body. This research investigates the effect of Transforming Growth Factor Beta Induced Protein (TGFBI) on skin regeneration and wound healing through its ability to modulate cell migration and proliferation. Fibroblasts and immortalized human keratinocytes were used during the experiments. The immunofluorescence analysis of mouse skin tissue samples showed that TGFBI is expressed both in healthy and healing skin, namely in the dermis. Experiments with cultured skin cells showed that TGFBI does not affect the migration and proliferation of keratinocytes and fibroblasts.