Recent Submissions

  • In Vitro Studies of Persister Cells 

    Kaldalu, N; Hauryliuk, V; Turnbull, Kathryn Jane; Putrinš, M; Tenson, Tanel (Microbiol Mol Biol Rev, 2020-11-11)
    Many bacterial pathogens can permanently colonize their host and establish either chronic or recurrent infections that the immune system and antimicrobial therapies fail to eradicate. Antibiotic persisters (persister cells) ...
  • The genetic architecture of sporadic and multiple consecutive miscarriage 

    Laisk, Triin; Soares, Ana Luiza G.; Lindgren, Cecilia M.; Ferreira, Teresa; Painter, Jodie N.; Censin, Jenny C.; Laber, Samantha; Bacelis, Jonas; Chen, Chia-Yen; Lepamets, Maarja; Lawlor, Deborah A.; Mägi, Reedik; Medland, Sarah E.; Granne, Ingrid; Walters, Robin G.; Nielsen, Rasmus; Neale, Benjamin M.; Martin, Nicholas G.; Li, Liming; Jacobsson, Bo; Conrad, Donald F.; Chen, Zhengming; Werge, Thomas; Zondervan, Krina; Snieder, Harold; Salumets, Andres; Seminara, Stephanie; Lippincott, Margaret; Nyholt, Dale R.; Nordentoft, Merete; Njølstad, Pål R.; Mortensen, Preben B.; Mors, Ole; Morris, Andrew P.; Montgomery, Grant W.; Metspalu, Andres; Lind, Penelope A.; Kukushkina, Viktorija; Kartsonaki, Christiana; Juodakis, Julius; Johansson, Stefan; Jin, Xin; Hougaard, David M.; Helgeland, Øyvind; Bybjerg-Grauholm, Jonas; Gordon, Scott D.; Børglum, Anders D.; Becker, Christian M.; Yang, Ling; Andersen, Marianne S.; Southcombe, Jennifer; Ramu, Avinash; Millwood, Iona Y.; Liu, Siyang; Lin, Kuang (Nature Communications, 2020-11-25)
    Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic ...
  • Understanding the mechanisms of endometrial receptivity through integration of ‘omics’ data layers 

    Kukuškina, Viktorija (2020-05-28)
    Maailma Terviseorganisatsiooni statistika väidab, et umbes 10% püsisuhetes olevatest naistest on ühel või teisel põhjusel viljatud. Naise viljakust mõjutab välja palju erinevaid faktoreid ning setõttu on viljatuse põhjuste ...
  • Utilising FGF2, IGF2 and FSH in serum-free protocol for long-term in vitro cultivation of primary human granulosa cells 

    Hensen, Kati; Pook, Martin; Sikut, Anu; Org, Tõnis; Maimets, Toivo; Salumets, Andres; Kurg, Ants (2020)
    Human granulosa cells acquired as leftover from IVF treatment can be used to study infertility problems and area valuable tool in the research of follicle maturation and ovulation. There is a need for more defined and ...
  • Incorporating the radiological effects and environmental impact assessment of naturally occurring radioactive materials (NORM) into the life cycle environmental optimisation of bauxite residue (BR) valorisation 

    Joyce, Peter James; Goronovski, Andrei; Tkaczyk, Alan Henry; Björklund, Anna (Bauxite Residue Valorisation and Best Practices, 2015-10)
    Bauxite Residue (BR) is a potentially valuable source of metals and construction materials, which the ETN REDMUD project aims to develop technologies to exploit. Bauxite contains low levels of Naturally Occurring Radioactive ...
  • A framework for including enhanced exposure to naturally occurring radioactive materials (NORM) in LCA 

    Joyce, Peter James; Goronovski, Andrei; Tkaczyk, Alan Henry; Björklund, Anna (The International Journal of Life Cycle Assessment, 2016-11-22)
    Despite advances in the development of impact categories for ionising radiation, the focus on artificial radionuclides produced in the nuclear fuel cycle means that the potential impacts resulting from increased exposure ...
  • Radiological assessment of the Bayer process 

    Goronovski, Andrei; Vind, Johannes; Vassiliadou, Vicky; Panias, Dimitrios; Tkaczyk, Alan Henry (Minerals Engineering, 2019-04-13)
    Naturally occurring radionuclides were studied through the Bayer process by calculating their mass flows. Aluminium of Greece (AoG) provided sample materials and plant data from several process stages. Measurements of ...
  • Radiological Assessment of the Bauxite Residue Valorization Chain 

    Goronovski, Andrei; Tkaczyk, Alan Henry (Journal of Radioanalytical and Nuclear Chemistry, 2019-07-27)
    The behavior of radionuclides in the bauxite residue valorization chain has been analyzed, and accumulation ratios have been measured for secondary residues produced after recovery of valuable metals. Key analysis outcomes ...
  • IMPACT ASSESSMENT OF ENHANCED EXPOSURE FROM NATURALLY OCCURRING RADIOACTIVE MATERIALS (NORM) WITHIN LCA 

    Goronovski, Andrei; Joyce, Peter James; Finnveden, Göran; Tkaczyk, Alan Henry; Björklund, Anna (Journal of Cleaner Production, 2018-01-20)
    The potential impact of ionising radiation from enhanced exposure to Naturally Occurring Radioactive Materials (NORM) to humans and the environment is not currently accounted for sufficiently in Life Cycle Assessment (LCA). ...
  • Assessment of NORM in bauxite residue to facilitate valorization 

    Goronovski, Andrei; Tkaczyk, Alan H. (2nd Bauxite Residue Valorisation and Best Practices Conference, 2018)
    In the new Euratom Basic Safety Standard (BSS), materials with elevated concentrations of natural radionuclides can be considered as a potential source of radiological exposure. Such materials are often found in mining and ...
  • Distribution of uranium, thorium and potassium in the Bayer process 

    Goronovski, Andrei; Vind, Johannes; Vassiliadou, Vicky; Panias, Dimitrios; Tkaczyk, Alan Henry (2nd Bauxite Residue Valorisation and Best Practices Conference, 2018)
    Uranium, thorium, potassium and their decay product mass flows were analysed in the Bayer process. Gamma-ray spectroscopy was used to measure the radionuclide content in samples provided by Aluminium of Greece and to model ...
  • Performance evaluation of Monte Carlo simulation: Case study of Monte Carlo approximation vs. analytical solution for a chi-squared distribution 

    Ohvril, Hanno; Tkaczyk, Alan H; Saari, Peeter; Kollo, Tõnu; Mauring, Koit; Post, Piia; Vilbaste, Martin; Vedru, Jüri; Ipbüker, Cagatay (IOP Publishing, 2020)
    The guide to the expression of uncertainty in measurement (GUM) describes the law of propagation of uncertainty for linear models based on the first-order Taylor series approximation of Y = f(X1, X2, …, XN). However, for ...
  • Creating basis for introducing non‐invasive prenatal testing in the Estonian public health setting 

    Žilina, Olga; Rekker, Kadri; Kaplinski, Lauris; Sauk, Martin; Paluoja, Priit; Teder, Hindrek; Ustav, Eva‐Liina; Tõnisson, Neeme; Reimand, Tiia; Ridnõi, Konstantin; Palta, Priit; Vermeesch, Joris Robert; Krjutškov, Kaarel; Kurg, Ants; Salumet, Andres (John Wiley & Sons, Ltd., 2019-11)
    Objective The study aimed to validate a whole‐genome sequencing‐based NIPT laboratory method and our recently developed NIPTmer aneuploidy detection software with the potential to integrate the pipeline into prenatal ...
  • In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages 

    Esteki, Masoud Zamani; Viltrop, Triin; Tšuiko, Olga; Tiirats, Airi; Koel, Mariann; Nõukas, Margit; Žilina, Olga; Teearu, Katre; Marjonen, Heidi; Kahila, Hanna; Meekels, Jeroen; Söderström-Anttila, Viveca; Suikkari, Anne-Maria; Tiitinen, Aila; Mägi, Reedik; Kõks, Sulev; Kaminen-Ahola, Nina; Kurg, Ants; Voet, Thierry; Vermeesch, Joris Robert; Salumets, Andres (Nature Medicine, 2019-11-04)
    Although chromosomal instability (CIN) is a common phenomenon in cleavage-stage embryogenesis following in vitro fertilization (IVF)1,2,3, its rate in naturally conceived human embryos is unknown. CIN leads to mosaic embryos ...
  • A molecular tool for menstrual cycle phase dating of endometrial samples in endometriosis transcriptome studies 

    Saare, Merli; Merli, Triin; Teder, Hindrek; Paluoja, Priit; Palta, Priit; Koel, Mariann; Kirss, Fred; Karro, Helle; Sõritsa, Deniss; Salumets, Andres; Krjutškov, Kaarel; Peters, Maire (2019)
    Transcriptome profiling of 57 endometrial receptivity genes specifies the menstrual cycle phase of endometrial samples.
  • A dual colour FISH method for routine validation of sexed Bos taurus semen 

    Reinsalu, Olavi; Mikelsaar, Ruth; Mikelsaar, Aavo-Valdur; Hallap, Triin; Jaakma, Ülle; Padrik, Peeter; Kavak, Ants; Salumets, Andres; Kurg, Ants (BMC Veterinary Research, 2019)
    Background Usage of sexed semen that allows to choose the gender of the calves, is commonly practiced in livestock industry as a profitable breeding alternative, especially in dairy farming. The flow cytometric cell sorting ...
  • GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology 

    Bovijn, J; Jackson, L; Censin, J; Chen, CY; Laisk, T; Laber, S; Ferreira, T; Pulit, SL; Glastonbury, CA; Smoller, JW; Harrison, JW; Ruth, KS; Beaumont, RN; Jones, SE; Tyrrell, J; Wood, AR; Weedon, MN; Mägi, R; Neale, B; Lindgren, CM; Murray, A; Holmes, MV (2019)
  • Genome-wide haplotyping embryos developing from 0PN and 1PN zygotes increases transferrable embryos in PGT-M. 

    Destouni, Aspasia; Dimitriadou, Eftychia; Masset, Heleen; Debrock, Sophie; Melotte, Cindy; Bogaert, Kris Van Den; Esteki, Masoud Zamani; Ding, Jia; Voet, Thiery; Denayer, Ellen; de Ravel, Thomy; Legius, Eric; Meuleman, Christel; Peeraer, Karen; Vermeesch, Joris R (2018)
    STUDY QUESTION Can genome-wide haplotyping increase success following preimplantation genetic testing for a monogenic disorder (PGT-M) by including zygotes with absence of pronuclei (0PN) or the presence of only one ...
  • TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting 

    Teder, Hindrek; Koel, Mariann; Paluoja, Priit; Jatsenko, Tatjana; Rekker, Kadri; Laisk-Podar, Triin; Kukuškina, Viktorija; Velthut-Meikas, Agne; Fjodorova, Olga; Peters, Maire; Kere, Juha; Salumets, Andres; Palta, Priit; Krjutškov, Kaarel (2018)
    Targeted next-generation sequencing (NGS) methods have become essential in medical research and diagnostics. In addition to NGS sensitivity and high-throughput capacity, precise biomolecule counting based on unique molecular ...
  • Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria 

    Day, Felix; Karaderi, Tugce; Jones, Michelle R; Meun, Cindy; He, Chunyan; Drong, Alex; Kraft, Peter; Lin, Nan; Huang, Hongyan; Broer, Linda; Magi, Reedik; Saxena, Richa; Laisk-Podar, Triin; Urbanek, Margrit; Welt, Corrine K; Lindgren, Cecilia M; Franks, Steve; Thorsteinsdottir, Unnur; Stefansson, Kari; Ong, Ken; Anttila, Verneri; Neale, Benjamin M; Jarvelin, Marjo-Riitta; Hayes, Geoffrey M; Thorleifsson, Gudmar; Fernandez-Tajes, Juan; Mahajan, Anubha; Mullin, Benjamin H; Stuckey, Bronwyn G.A; Spector, Timothy D.; Wilson, Scott G; Goodarzi, Mark O; Davis, Lea; Obermeyer-Pietsch, Barbara; Uitterlinden, Andre G; Fauser, Bart; Kowalska, Irina; Visser, Jenny A; Anderson, Marianne; McCarthy, Mark I; Morin-Papunen, Laure; Salumets, Andres; Stener-Victorin, Elisabet; Ehrmann, David; Legro, Richard S; Styrkarsdottir, Unnur; Perry, John; Dunaif, Andrea; Laven, Joop S.E. (2018)
    Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have metabolic disturbances including insulin resistance ...

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