Recent Submissions

  • A widespread toxin-antitoxin system exploiting growth control via alarmone signaling 

    Tenson, Tanel; Hauryliuk, Vasili; Atkinson, Gemma; Jimmy, S; Saha, CK; Kurata, T; Stavropoulos, C; Oliveira, S; Koh, A; Cepauskas, A; Takada, Hiraku; Rejman, D; Strahl, D; Garcia-Pino, A (National Academy of Sciences, 2020-05-12)
    Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the alarmone (p)ppGpp, a nucleotide second messenger. (p)ppGpp rewires bacterial transcription and metabolism to cope with stress, and, at ...
  • Dividing subpopulation of Escherichia coli in stationary phase 

    Tenson, Tanel; Jõers, Arvi; Liske, Eliis (Elsevier, 2020-06)
    The bacterial growth cycle contains different phases: after the growth substrate is exhausted or the toxic waste products accumulate the growth stops. In this non-growing culture the number of colony forming bacteria remains ...
  • Analysis of nucleotide pools in bacteria using HPLC-MS in HILIC mode 

    Zbornikova, E; Hauryliuk, Vasili; Reyman, D; Krasny, L; Knejzlik, Z (Elsevier, 2019-12-01)
    Nucleotides, nucleosides and their derivatives are present in all cells at varying concentrations that change with the nutritional, and energetic status of the cell. Precise measurement of the concentrations of these ...
  • Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues 

    Bumann, Dirk; Fanous, Joseph; Li, J; Goormaghtigh, F (F1000 research, 2019-10-21)
    Antibiotic chemotherapy effectively cures many infections caused by susceptible bacterial pathogens. However, in some cases, even extended treatment duration does not completely eradicate the pathogenic bacteria from host ...
  • A diarylamine derived from anthranilic acid inhibits ZIKV replication 

    Silva, Suely; Shimizu, Jaqueline Farinha; Oliveira, Debora Morales; Assis, LR; Bittar, Cintia; Mottin, Melina; Sousa, BKP; Mesquita, NCMR; Regasini, LO; Rahal, Paula; Oliva, Glaucius; Perryman, AL; Ekins, S; Andrade, CH; Goulart, LR; Sabino-Silva, R; Merits, Andres; Harris, M; Jardim, ACG (PLOS ONE, 2019-11-27)
    Zika virus (ZIKV) is a mosquito-transmitted Flavivirus, originally identified in Uganda in 1947 and recently associated with a large outbreak in South America. Despite extensive efforts there are currently no approved ...
  • E2 protein is the major determinant of specificity at the human papillomavirus origin of replication 

    Laaneväli, Airiin; Ustav, Mart; Ustav, Ene; Piirsoo, M (PLOS ONE, 2019-10-23)
    The replication of human papillomavirus (HPV) genomes requires E1 and E2 proteins as the viral trans-factors and the replication origin, located in the URR, as a cis-element. The minimal requirements for an HPV replication ...
  • Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle 

    Piirsoo, Alla; Pink, Anne; Kasak, Lagle; Kala, Martin; Kasvandik, Sergo; Ustav, Marko; Piirsoo, Marko (PLOS ONE, 2019-11-26)
    The Sonic Hedgehog (Shh) signalling pathway plays multiple roles during embryonic development and under pathological conditions. Although the core components of the Shh pathway are conserved, the regulation of signal ...
  • Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-β 

    Wu, Zhen; Zhang, W; Wu, Y; Wang, T; Wu, S; Wang, M; Jia, R; Zhu, D; Liu, M; Zhao, X; Yang, Q; Wu, Y; Zhang, S; Liu, Y; Zhang, L; Yu, Y; Pan, L; Merits, Andres; Chen, S; Cheng, A (Journal of immunology, 2019-12-15)
    Duck Tembusu virus (DTMUV) is a newly emerged causative agent of avian disease. The protease-dependent immune evasion of flaviviruses has been reported; however, the molecular details of this process are unclear. In this ...
  • Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae and Contact to Animals in Estonia 

    Telling, Kaidi; Brauer, Age; Laht, Mailis; Kalmus, Piret; Toompere, Karolin; Kisand, Veljo; Maimets, Matti; Remm, Maido; Tenson, Tanel; Lutsar, Irja (Microorganisms, 2020-07-27)
    We have attempted to define the prevalence and risk factors of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-Enterobacteriaceae) carriage, and to characterize antimicrobial susceptibility, beta-lactamase ...
  • Muropeptides Stimulate Growth Resumption from Stationary Phase in Escherichia coli 

    Jõers, Arvi; Vind, Kristiina; Hernandez, Sara B; Maruste, Regina; Pereira, Marta; Brauer, Age; Remm, Maido; Cava, Felipe; Tenson, Tanel (Nature publishing group, 2019-12-02)
    When nutrients run out, bacteria enter a dormant metabolic state. This low or undetectable metabolic activity helps bacteria to preserve their scant reserves for the future needs, yet it also diminishes their ability to ...
  • Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis 

    Bösl, Korbinian; Ianevski, Aleksandr; Than, Thoa T; Andersen, Petter; Kuivanen, Suvi; Teppor, Mona; Zusinaite, Eva; Dumpis, Uga; Vitkauskiene, Astra; Cox, Rebecca J; Kallio-Kokko, Hannimari; Bergqvist, Anders; Tenson, Tanel; Merits, Andres; Oksenych, Valentyn; Bjoras, Magnar; Anthonsen, Marit W; Shum, David; Kaarbo, Mari; Vapalahti, Olli; Windisch, Marc P; Superti-Furga, Giulio; Snijder, Berend; Kainov, Denis; Kandasamy, Richard K (Frontiers in Immunology, 2019-10-04)
    Viruses are one of the major causes of acute and chronic infectious diseases and thus a major contributor to the global burden of disease. Several studies have shown how viruses have evolved to hijack basic cellular pathways ...
  • Understanding the mechanisms of endometrial receptivity through integration of ‘omics’ data layers 

    Kukuškina, Viktorija (2020-05-28)
    Maailma Terviseorganisatsiooni statistika väidab, et umbes 10% püsisuhetes olevatest naistest on ühel või teisel põhjusel viljatud. Naise viljakust mõjutab välja palju erinevaid faktoreid ning setõttu on viljatuse põhjuste ...
  • Utilising FGF2, IGF2 and FSH in serum-free protocol for long-term in vitro cultivation of primary human granulosa cells 

    Hensen, Kati; Pook, Martin; Sikut, Anu; Org, Tõnis; Maimets, Toivo; Salumets, Andres; Kurg, Ants (2020)
    Human granulosa cells acquired as leftover from IVF treatment can be used to study infertility problems and area valuable tool in the research of follicle maturation and ovulation. There is a need for more defined and ...
  • Incorporating the radiological effects and environmental impact assessment of naturally occurring radioactive materials (NORM) into the life cycle environmental optimisation of bauxite residue (BR) valorisation 

    Joyce, Peter James; Goronovski, Andrei; Tkaczyk, Alan Henry; Björklund, Anna (Bauxite Residue Valorisation and Best Practices, 2015-10)
    Bauxite Residue (BR) is a potentially valuable source of metals and construction materials, which the ETN REDMUD project aims to develop technologies to exploit. Bauxite contains low levels of Naturally Occurring Radioactive ...
  • A framework for including enhanced exposure to naturally occurring radioactive materials (NORM) in LCA 

    Joyce, Peter James; Goronovski, Andrei; Tkaczyk, Alan Henry; Björklund, Anna (The International Journal of Life Cycle Assessment, 2016-11-22)
    Despite advances in the development of impact categories for ionising radiation, the focus on artificial radionuclides produced in the nuclear fuel cycle means that the potential impacts resulting from increased exposure ...
  • Radiological assessment of the Bayer process 

    Goronovski, Andrei; Vind, Johannes; Vassiliadou, Vicky; Panias, Dimitrios; Tkaczyk, Alan Henry (Minerals Engineering, 2019-04-13)
    Naturally occurring radionuclides were studied through the Bayer process by calculating their mass flows. Aluminium of Greece (AoG) provided sample materials and plant data from several process stages. Measurements of ...
  • Radiological Assessment of the Bauxite Residue Valorization Chain 

    Goronovski, Andrei; Tkaczyk, Alan Henry (Journal of Radioanalytical and Nuclear Chemistry, 2019-07-27)
    The behavior of radionuclides in the bauxite residue valorization chain has been analyzed, and accumulation ratios have been measured for secondary residues produced after recovery of valuable metals. Key analysis outcomes ...
  • IMPACT ASSESSMENT OF ENHANCED EXPOSURE FROM NATURALLY OCCURRING RADIOACTIVE MATERIALS (NORM) WITHIN LCA 

    Goronovski, Andrei; Joyce, Peter James; Finnveden, Göran; Tkaczyk, Alan Henry; Björklund, Anna (Journal of Cleaner Production, 2018-01-20)
    The potential impact of ionising radiation from enhanced exposure to Naturally Occurring Radioactive Materials (NORM) to humans and the environment is not currently accounted for sufficiently in Life Cycle Assessment (LCA). ...
  • Assessment of NORM in bauxite residue to facilitate valorization 

    Goronovski, Andrei; Tkaczyk, Alan H. (2nd Bauxite Residue Valorisation and Best Practices Conference, 2018)
    In the new Euratom Basic Safety Standard (BSS), materials with elevated concentrations of natural radionuclides can be considered as a potential source of radiological exposure. Such materials are often found in mining and ...
  • Distribution of uranium, thorium and potassium in the Bayer process 

    Goronovski, Andrei; Vind, Johannes; Vassiliadou, Vicky; Panias, Dimitrios; Tkaczyk, Alan Henry (2nd Bauxite Residue Valorisation and Best Practices Conference, 2018)
    Uranium, thorium, potassium and their decay product mass flows were analysed in the Bayer process. Gamma-ray spectroscopy was used to measure the radionuclide content in samples provided by Aluminium of Greece and to model ...

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