Recent Submissions

  • In Vitro Studies of Persister Cells 

    Kaldalu, N; Hauryliuk, V; Turnbull, Kathryn Jane; Putrinš, M; Tenson, Tanel (Microbiol Mol Biol Rev, 2020-11-11)
    Many bacterial pathogens can permanently colonize their host and establish either chronic or recurrent infections that the immune system and antimicrobial therapies fail to eradicate. Antibiotic persisters (persister cells) ...
  • Uncovering the Role of the E1 Protein in Different Stages of Human Papillomavirus 18 Genome Replication 

    Ustav, M; Piirsoo, A; Piirsoo, M; Kala, M; Sankovski, E (journal of virology, 2020-09-29)
    The life cycle of human papillomaviruses (HPVs) comprises three distinct phases of DNA replication: initial amplification, maintenance of the genome copy number at a constant level, and vegetative amplification. The viral ...
  • Organometallic Complex Strongly Impairs Chikungunya Virus Entry to the Host Cells 

    de Oliveira, DM; Merits, A; de Andrade Santos, I; Oliveira Silva Martins, D; Garcia Gonçalves, Y; Cardoso-Sousa, L; Sabino-Silva, R; Von Poelhsitz, G; de Faria Franca, E; Nicolau Jr, N; Colombelli Pacca, C; Harris, M; Gomes Jardim, AC (2020-12-15)
    Chikungunya fever is a disease caused by the Chikungunya virus (CHIKV) that is transmitted by the bite of the female of Aedes sp. mosquito. The symptoms include fever, muscle aches, skin rash, and severe joint pains. The ...
  • Dividing subpopulation of Escherichia coli in stationary phase 

    Jõers, A; Liske, E; Tenson, Tanel (Elsevier, 2020)
    The bacterial growth cycle contains different phases: after the growth substrate is exhausted or the toxic waste products accumulate the growth stops. In this non-growing culture the number of colony forming bacteria remains ...
  • Discovery and development of safe-in-man broad-spectrum antiviral agents 

    Andersen, PI; Kantele, A; Tenson, Tanel; Kainov, Denis E; Ianevski, A; Lysvand, H; Vitkauskiene, A; Oksenych, V; Bjoras, M; Telling, K; Lutsar, I; Dumpis, U; Irie, Y (Americal chemical society, 2020-04)
    Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral ...
  • Intracellular Staphylococcus aureus persisters upon antibiotic exposure 

    Peyrusson, F; Varet, H; Nguyen, TK; Legendre, R; Sismeiro, O; Coppee, Y; Woltz, C; Van Bambeke, F; Tenson, Tanel (Nature Research, 2020-05-04)
    Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus persisters within infected host cells. We ...
  • Potential Antiviral Options against SARS-CoV-2 Infection 

    Ianevski, A; Yao, R; Hoysaeter Venstad, M; Biza, S; Zusinaite, E; Reisberg, T; Lysvand, H; Loseth, Kirsti; Malm Landsem, V; Fossum Malmring, V; Oksenych, V; Erlandsen, S; Aas, Per Arne; Hagen, L; Pettersen, CH; Tenson, Tanel; Afset, JE; Nordbo, SA; Bjoras, M; Kainov, D (Viruses, 2020-06-13)
    As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United ...
  • Characteristics of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae and Contact to Animals in Estonia 

    Telling, K; Brauer, A; Laht, Mailis; Kalmus, P; Toompere, K; Kisand, V; Maimets, Matti; Remm, M; tenson, T; Lutsar, Irja (Microorganisms, 2020-07-27)
    We have attempted to define the prevalence and risk factors of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-Enterobacteriaceae) carriage, and to characterize antimicrobial susceptibility, beta-lactamase ...
  • Microbiome of root vegetables-a source of gluten-degrading bacteria 

    Kõiv, Viia; Adamberg, K; Adamberg, A; Sumeri, I; Kasvandik, S; Kisand, V; Maivali, Ü; Tenson, T (Appl Microbiol Biotechnol, 2020-10)
    Gluten is a cereal protein that is incompletely digested by human proteolytic enzymes that create immunogenic peptides that accumulate in the gastrointestinal tract (GIT). Although both environmental and human bacteria ...
  • Identification and Tracking of Antiviral Drug Combinations 

    Ianevski, A; Tenson, T; Ustav, M; Rouan, Y; Biza, S; Zusinaite, E; Mannik, A; Kivi, G; Planken, A; Kurg, Kristiina; Tombak, E; Shtaida, N; Kulesskyi, E; Jo, E; Yang, J; Lysvand, H; Loseth, K; Oksenych, V; aas, Per Arne; Vitkauskiene, A; Windisch, M; Hoysaeter Venstad, M; Nordbo, S; Ustav Jr, M; Bjoras, M; Kainov, Denis E (Viruses, 2020-10-18)
    Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to ...
  • Antibacterial Porous Electrospun Fibers as Skin Scaffolds for Wound Healing Applications 

    Lanno, G; Ramos, C; Putrinš, M; Preem, L; Kogermann, K; Tenson, T (Amrican Chemical Society, 2020-11-12)
    Electrospun fiber scaffolds have a huge potential for the successful treatment of infected wounds based on their unique properties. Although several studies report novel drug-loaded electrospun fiber-based biomaterials, ...
  • Hfq-Assisted RsmA Regulation Is Central to Pseudomonas aeruginosa Biofilm Polysaccharide PEL Expression 

    Irie, Y; La Mensa, A; Murina, V; Hauryliuk, Vasili; Shingler, V; Tenson, Tanel (Frontiers in Microbiology, 2020-11-17)
    To appropriately switch between sessile and motile lifestyles, bacteria control expression of biofilm-associated genes through multiple regulatory elements. In Pseudomonas aeruginosa, the post-transcriptional regulator ...
  • Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP 

    Hauryliuk, Vasili; Takada, Hiraku; Crowe-McAuliffe, C; Murina, V; Polte, C; Kasvandik, Sergo; Tenson, Tanel; Ignatova, Z; Atkinson, Gemma; Wilson, Daniel N (Molecular Cell, 2020-11-30)
    In all branches of life, stalled translation intermediates are recognized and processed by ribosome-associated quality control (RQC) pathways. RQC begins with the splitting of stalled ribosomes, leaving an unfinished ...
  • The genetic architecture of sporadic and multiple consecutive miscarriage 

    Laisk, Triin; Soares, Ana Luiza G.; Lindgren, Cecilia M.; Ferreira, Teresa; Painter, Jodie N.; Censin, Jenny C.; Laber, Samantha; Bacelis, Jonas; Chen, Chia-Yen; Lepamets, Maarja; Lawlor, Deborah A.; Mägi, Reedik; Medland, Sarah E.; Granne, Ingrid; Walters, Robin G.; Nielsen, Rasmus; Neale, Benjamin M.; Martin, Nicholas G.; Li, Liming; Jacobsson, Bo; Conrad, Donald F.; Chen, Zhengming; Werge, Thomas; Zondervan, Krina; Snieder, Harold; Salumets, Andres; Seminara, Stephanie; Lippincott, Margaret; Nyholt, Dale R.; Nordentoft, Merete; Njølstad, Pål R.; Mortensen, Preben B.; Mors, Ole; Morris, Andrew P.; Montgomery, Grant W.; Metspalu, Andres; Lind, Penelope A.; Kukushkina, Viktorija; Kartsonaki, Christiana; Juodakis, Julius; Johansson, Stefan; Jin, Xin; Hougaard, David M.; Helgeland, Øyvind; Bybjerg-Grauholm, Jonas; Gordon, Scott D.; Børglum, Anders D.; Becker, Christian M.; Yang, Ling; Andersen, Marianne S.; Southcombe, Jennifer; Ramu, Avinash; Millwood, Iona Y.; Liu, Siyang; Lin, Kuang (Nature Communications, 2020-11-25)
    Miscarriage is a common, complex trait affecting ~15% of clinically confirmed pregnancies. Here we present the results of large-scale genetic association analyses with 69,054 cases from five different ancestries for sporadic ...
  • A widespread toxin-antitoxin system exploiting growth control via alarmone signaling 

    Tenson, Tanel; Hauryliuk, Vasili; Atkinson, Gemma; Jimmy, S; Saha, CK; Kurata, T; Stavropoulos, C; Oliveira, S; Koh, A; Cepauskas, A; Takada, Hiraku; Rejman, D; Strahl, D; Garcia-Pino, A (National Academy of Sciences, 2020-05-12)
    Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the alarmone (p)ppGpp, a nucleotide second messenger. (p)ppGpp rewires bacterial transcription and metabolism to cope with stress, and, at ...
  • Dividing subpopulation of Escherichia coli in stationary phase 

    Tenson, Tanel; Jõers, Arvi; Liske, Eliis (Elsevier, 2020-06)
    The bacterial growth cycle contains different phases: after the growth substrate is exhausted or the toxic waste products accumulate the growth stops. In this non-growing culture the number of colony forming bacteria remains ...
  • Analysis of nucleotide pools in bacteria using HPLC-MS in HILIC mode 

    Zbornikova, E; Hauryliuk, Vasili; Reyman, D; Krasny, L; Knejzlik, Z (Elsevier, 2019-12-01)
    Nucleotides, nucleosides and their derivatives are present in all cells at varying concentrations that change with the nutritional, and energetic status of the cell. Precise measurement of the concentrations of these ...
  • Antibiotic chemotherapy against heterogeneous pathogen populations in complex host tissues 

    Bumann, Dirk; Fanous, Joseph; Li, J; Goormaghtigh, F (F1000 research, 2019-10-21)
    Antibiotic chemotherapy effectively cures many infections caused by susceptible bacterial pathogens. However, in some cases, even extended treatment duration does not completely eradicate the pathogenic bacteria from host ...
  • A diarylamine derived from anthranilic acid inhibits ZIKV replication 

    Silva, Suely; Shimizu, Jaqueline Farinha; Oliveira, Debora Morales; Assis, LR; Bittar, Cintia; Mottin, Melina; Sousa, BKP; Mesquita, NCMR; Regasini, LO; Rahal, Paula; Oliva, Glaucius; Perryman, AL; Ekins, S; Andrade, CH; Goulart, LR; Sabino-Silva, R; Merits, Andres; Harris, M; Jardim, ACG (PLOS ONE, 2019-11-27)
    Zika virus (ZIKV) is a mosquito-transmitted Flavivirus, originally identified in Uganda in 1947 and recently associated with a large outbreak in South America. Despite extensive efforts there are currently no approved ...
  • E2 protein is the major determinant of specificity at the human papillomavirus origin of replication 

    Laaneväli, Airiin; Ustav, Mart; Ustav, Ene; Piirsoo, M (PLOS ONE, 2019-10-23)
    The replication of human papillomavirus (HPV) genomes requires E1 and E2 proteins as the viral trans-factors and the replication origin, located in the URR, as a cis-element. The minimal requirements for an HPV replication ...

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