The role of the serotonin transporter and 5-HT1A receptor genes promoter polymorphisms 5-HTTLPR and C(-1019)G in impulsivity and traffic violations
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This papers purpose was to use appropriate statistical tests to pinpoint the relationships between impulsivity with its adaptive and maladaptive facets, two serotonergic system gene promoter polymorphisms - 5-HTTLPR and C(-1019)G, and different traffic violations and accidents. The sample was the sum of two previous study samples from 2007 and 2014 (n = 2113). The study found that traffic violators were higher in adaptive impulsivity and that 5-HTTPLR La/La homozygotes were more likely traffic violators. A polymorphic interaction of 5-HTTLPR+C(-1019)G showed that contrary to the hypotheses, La/La+G/G genotype carriers were more likely to speed while S allele+C/C genotype carriers were least likely to violate traffic law which may point to an interactive effect on the desensitization of 5-HT1a autoreceptors.
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