The Process of Creating a Scientific Knowledge Base for Pharmacogenetic Testing
Pharmacogenetics is a branch of personalised medicine that investigates the impact of genetic fac-tors on drug response. Adequate IT solutions are the key components of applying pharmacogenetic knowledge to clinical practice. This thesis describes the process of designing and implementing a curated scientific knowledge base to be used by a software-based medical device for pharmaco-genetic testing. Based on scientific literature, a prototype is built to identify main domain objects and processes for curating the knowledge base. The final implementation is created by using the Qure Data Management Platform.
Knowledge base, pharmacogenetics, data curation