Gene expression profiling of endometrial polyp

Abstract

Endometrial polyps (EP) are benign growths of endometrial tissue that occur frequently in women, the molecular and genetic causes of which are still unclear. This study compared the transcriptomes of endometrial tissue and EP biopsies to detect changes in gene expression and analyzed cellular diversity using single-cell RNA sequencing. The results of the work showed that the transcriptome profiles of EP and endometrium in tissue biopsies are very similar and only individual differences were detected at the level of gene expression. Single-cell sequencing of the polyp confirmed that the cellular diversity of the EP and endometrium is very similar, but identified three genes (BNC2, CSMD1 and LINC01060) that were differently expressed in the perivascular cell cluster. The importance of these genes in the pathogenesis of EP needs to be confirmed by further studies.