Õhureostuse põhjuslik mõju astmariskile
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Õhureostus on üks peamisi astma riskitegureid. Mitmed varasemad uuringud on leidnud, et peened tahked osakesed õhus on eriti ohtlikud ning soodustavad astma teket.
Käesoleva bakalaureusetöö eesmärk on uurida põhjuslikke seoseid välisõhu PM₂.₅ kontsentratsiooni ja astmariski vahel. Analüüsis arvestatakse ka teadaolevaid segavaid tegureid. Töös on kasutatud Eesti geenivaramu andmeid ja EXPANSE projekti poolt mudeldatud keskkonnaandmeid. Statistiline analüüs koosneb logistilisest regressioonist ja G-hinnangu meetodist. Tulemuste põhjal võib järeldada, et vaadeldud valimi puhul võib PM₂.₅ kontsentratsioonil tõepoolest olla põhjuslik mõju astmariskile.
Air pollution is one of the main risk factors for asthma. Several previous studies claimed that fine particulate matter is especially harmful and is associated with an increased risk of asthma. The aim of the bachelor’s thesis is to study the causal relationship between ambient PM₂.₅ concentration and the risk of asthma. The analysis also takes into account known confounding factors. The thesis is based on the data of the Estonian Biobank and environmental data modelled within the EXPANSE project. The statistical analysis includes logistic regression and the G-computation method. Based on the results, in the studied sample, it can be concluded that the concentration of PM₂.₅ may indeed have a causal effect on the risk of asthma.
Air pollution is one of the main risk factors for asthma. Several previous studies claimed that fine particulate matter is especially harmful and is associated with an increased risk of asthma. The aim of the bachelor’s thesis is to study the causal relationship between ambient PM₂.₅ concentration and the risk of asthma. The analysis also takes into account known confounding factors. The thesis is based on the data of the Estonian Biobank and environmental data modelled within the EXPANSE project. The statistical analysis includes logistic regression and the G-computation method. Based on the results, in the studied sample, it can be concluded that the concentration of PM₂.₅ may indeed have a causal effect on the risk of asthma.
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õhureostus, põhjuslik mõju, astma, air pollution, causal inference, asthma